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NCT Number: NCT06662955

Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction

The closed kinetic chain (CKC) of terminal knee extension exercise (TKE) is designed to activate VM activity for knee injury training. This CKC exercise is effective for highest recruiting muscle activity, especially safe for post-operative knee surgery. The study of ACL reconstruction rehabilitation guideline suggests that exercises can be applied within the early phase of rehabilitation to prevent knee laxity and less knee pain compared to open chain exercise. Therefore, it is interesting to investigate the effects of TKE exercise synchronized with metronome pace on change of VM motor unit behavior in post operative ACL reconstruction. This study focuses on the immediate effect of 1-seesion TKE and expects that adding metronome during TKE will enhance neuromuscular control of VM and may change motor unit behavior.

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Key information

Conditions

Therapeutic Exercise Neuromuscular Function Physical Therapy Techniques

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Physical Therapy, Mahidol University

Salaya, Changwat Nakhon Pathom, 73170, Thailand

Location status: Recruiting

Location contact

Wanida Sawangnat, M.Sc.

CONTACT

[email protected]

+66 24415450 ext. 20220

About this study

This study investigates the effect of exercise with sensory integration technique on neuromuscular control in athletes with anterior cruciate ligament reconstruction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female participants who receive primary ACL reconstruction within 2 weeks with or without meniscus repair
  • No or mild resting pain (Numeric rating scale ≤ 3)
  • Reconstruction procedures using autograft including hamstrings or bone-patella bone grafts
  • Age range 18-35 years (33).
  • BMI of 18.5-25 kg/m² (34).
  • Tegner activity scale ≥ level 4

Exclusion criteria

  • Non-weight bearing within 2 weeks after the operation (prescription from surgeon)
  • Hearing problem, such as being unable to hear the metronome sound or being unable to synchronize exercises with the metronome correctly
  • Limitations in knee extension range caused by joint stiffness evaluated by using passive knee range of motion
  • Unable to perform active and passive ≥ 30º knee flexion on the operative side
  • History of serious injury or operation of lower back and lower extremities such as fracture
  • Lower back or lower extremities pain within 6 months before the study
  • On the pain killer medication

Treatment and study plan

audible cues

Behavioral

Terminal knee extension exercise with audible cues

Other names: Exercise with audible cues

Exercise

Behavioral

Terminal knee extension exercise

Primary outcomes

  1. Average motor unit firing rate (pulse per second, pps)

    Time frame: From enrollment to the end of treatment at 2 weeks

    Motor unit behavior of vastus medialis muscle: Average motor unit firing rate (pulse per second, pps)

Secondary outcomes

  1. Peak motor unit action potential (mV)

    Time frame: From enrollment to the end of treatment at 2 weeks

    Motor unit behavior of vastus medialis muscle: Peak motor unit action potential (mV)

Study contacts

Contact information is provided by the study sponsor or research team.

Komsak Sinsurin, PT, Ph.D., DPT

CONTACT

[email protected]

6855547313

Sakda Nitkotom, B.Sc.

CONTACT

[email protected]

0869853212

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Terminal Knee Extension Exercise Synchronize With Audible Cues on Motor Unit Behavior of Vastus Medialis Muscle in Athletes With Anterior Cruciate Ligament Reconstruction

Acronym: ACLR

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 29, 2024
Registry last updated
Dec 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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