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OpenTrials
Completed

NCT Number: NCT05702840

EXerCise wEight Loss

The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

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Key information

Conditions

Overweight and Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stuart Robert Gray

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obesity or overweight (BMI ≥ 25kg/m2).
  • Passing the Physical Activity Readiness Questionnaire (PAR-q+)

Exclusion criteria

  • Currently take part in more than 1.5 hours of structured exercise per week.
  • Having recently (<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss.
  • Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months.
  • Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Treatment and study plan

Resistance exercise training + weight loss group

Behavioral

Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period

Weight loss only group (WL)

Behavioral

Only following the weight watchers weight loss programme for a 12-week period

Primary outcomes

  1. Change in whole body lean mass

    Time frame: Change from baseline to 12 weeks

    whole body lean mass measured via bio-electrical impedance

Secondary outcomes

  1. Change in whole body fat mass

    Time frame: Change from baseline to 12 weeks

    whole body fat mass measured via bio-electrical impedance

  2. Change in body mass

    Time frame: Change from baseline to 12 weeks

    body mass measured on scales

  3. Change in vastus lateralis muscle thickness

    Time frame: Change from baseline to 12 weeks

    Muscle thickness of the vastus lateralis muscle measured via ultrasound

  4. Change in knee extensor maximal isometric torque

    Time frame: Change from baseline to 12 weeks

    Knee extensor maximal isometric torque measured during a maximal voluntary contraction

  5. Change in grip strength

    Time frame: Change from baseline to 12 weeks

    Grip strength measured with a hand held dynamometer

  6. Change in functional physical abilities

    Time frame: Change from baseline to 12 weeks

    A 30-second sit-to-stand test measured functional abilities

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

The Effects of a Home-based Resistance Training Programme on Body Composition and Muscle Function During Weight Loss in People With Overweight or Obesity: a Randomised Controlled Pilot Trial

Acronym: EXCEL

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 27, 2023
Registry last updated
Feb 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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