Exercise-training Before Coronary Artery Bypass Graft (CABG)

The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.

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Key information

Conditions

Angina Angina Pectoris Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Coronary Artery Disease Coronary Disease Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Norwegian University of Science and Technology

Trondheim, 7489, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Scheduled for CABG both with and without heart failure

Exclusion criteria

Unstable angina
Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
Participation in another study

Treatment and study plan

Exercise Training

Behavioral

Intensity controlled exercise training before the scheduled bypass surgery

Primary outcomes

Cardiovascular function and quality of life

Time frame: Before and up to 1 year after intervention

Secondary outcomes

Structure and function of cardiomyocytes

Time frame: After the intervention period
Cardiomyocyte structure and function

Time frame: after the intervention period

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Important dates

Study start: 2005
Primary completion: 2016
Study completion: 2016
First posted: Sep 22, 2005
Registry last updated: Feb 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed