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Completed

NCT Number: NCT03036332

Exercise Training and Metabolic Syndrome

The present study aimed to determine the effects of 16 weeks of aerobic interval training on quality of life and a set of clinical biomarkers.

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Key information

Conditions

Metabolic Syndrome Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Besides the traditional metabolic syndrome risk factors (dyslipidemia, raised blood pressure, central obesity and dysglycemia) subclinical disorders related to chronic inflammation and cell damage have been reported on metabolic syndrome. Therefore, regarding the systemic feature of metabolic syndrome, we investigated an new approach of aerobic interval training on several clinical biomarkers widely used. Such training used differs from current aerobic protocols in order to attenuate metabolic and musculoskeletal overload on untrained and unhealthy subjects.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having metabolic syndrome according to international diabetes foundations definition (IDF).
  • Age between 35 - 60 years and untrained subjects.

Exclusion criteria

  • Musculotendinous or osteoarticular injuries in the lower limbs and/or spine
  • Chronic pulmonary diseases
  • Neurological disorders
  • Kidney failure
  • High-risk cardiovascular diseases (Unstable angina pectoris, Uncompensated heart failure, complex ventricular arrhythmias or myocardial infarction during the last month).

Treatment and study plan

Aerobic Interval training

Behavioral

Carried out 3 times per week for 16 weeks

Primary outcomes

  1. Pro-inflammatory marker

    Time frame: 16 weeks

    Serum levels of C-reactive protein

Secondary outcomes

  1. Quality of life

    Time frame: 16 weeks

    The Medical Outcomes Study-Short Form 36 (SF-36)

  2. A set of clinical biomarkers

    Time frame: 16 weeks

    Serum levels lof Homocysteine; Creatinine, Creatine kinase (ck); creatine kinase MB (ck-mb); Troponin t; aspartate aminotransferase; alanine aminotransferase; and complete blood count.

Sponsors and collaborators

Lead sponsor

Universidade Estadual Paulista Júlio de Mesquita Filho

Other

Registry information

Official study title

Effects of Aerobic Interval Training on Clinical Biomarkers and Quality of Life in Metabolic Syndrome

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jan 30, 2017
Registry last updated
Jan 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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