Skip to main content
OpenTrials
Completed

NCT Number: NCT00701051

Exercise Training and Glucose Metabolism in Aging

Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are affected. In older adults, glucose metabolism may be affected by reduced skeletal muscle capillary supply, which limits insulin, glucose, and oxygen delivery to skeletal muscle. Reduced capillary supply to skeletal muscle is found in older individuals with impaired glucose tolerance and we hypothesize that this is due to reduced vascular growth factor expression, and chronic inflammation. Further, we hypothesize that reversal of a sedentary lifestyle through aerobic exercise training will increase insulin signaling and vascular growth factor expression, as well as decrease inflammation, to increase capillary supply to skeletal muscle, which contributes to improved glucose metabolism in older adults. This study will: 1) Determine the mechanisms underlying reduced skeletal muscle capillarization in older adults with impaired glucose tolerance; and 2) Determine the effect of aerobic exercise training-induced increases in skeletal muscle capillarization on glucose metabolism in older adults.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Type 2 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Impaired Glucose Tolerance (Prediabetes) Metabolic Diseases Nutritional and Metabolic Diseases Prediabetic State

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Maryland Health Care System, Baltimore

Baltimore, Maryland, 21201, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 50-75 years
  • Non-smoker >2 years
  • Body mass index = 18-35 kg/m2

Exclusion criteria

  • History of CAD or cerebrovascular disease that would preclude exercise
  • Implantable defibrillator
  • Active cancer
  • Chronic pulmonary, thyroid, renal, liver, or hematological disease
  • HIV positive or prone to malnutrition
  • Sickle cell anemia
  • Type 1 diabetes, or currently on medication to treat type 2 diabetes
  • Poorly-controlled type 2 diabetes
  • Poorly-controlled hypertension
  • Taking medications including: beta-blockers, oral steroids, warfarin, certain statins, hormone replacement therapy (HRT), oral contraceptives (OCP), thiazolidinediones (TZD), or chronic steroids or nonsteroidal analgesics (NSAIDS) that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior)
  • Allergic to lidocaine or heparin
  • Recent weight change (>5kg in 3 months)
  • Currently pregnant or nursing
  • Physical impairment limiting exercise
  • Dementia or unstable clinical depression

Treatment and study plan

Aerobic Exercise Training

Behavioral

24 weeks of aerobic exercise training: 3 times per week, 60 minutes per session, at 70% of maximal aerobic capacity

Detraining (cessation of exercise)

Behavioral

Cessation of exercise for 2 weeks

Primary outcomes

  1. Baseline Glucose Utilization

    Time frame: baseline

    Insulin-stimulated glucose uptake

  2. Glucose Utilization (Pre/Post Intervention)

    Time frame: baseline, 24 weeks, 26 weeks

    Insulin-stimulated glucose uptake

  3. Baseline Skeletal Muscle Capillarization

    Time frame: baseline

  4. Skeletal Muscle Capillarization (Pre/Post Intervention)

    Time frame: baseline, 24 weeks, 26 weeks

Secondary outcomes

  1. Baseline 2-hour Postprandial Glucose

    Time frame: baseline

  2. 2-hr Post-prandial Plasma Glucose Level

    Time frame: baseline, 24 weeks, 26 weeks

  3. Baseline Cardiorespiratory Fitness

    Time frame: baseline

    maximal oxygen consumption

  4. Cardiorespiratory Fitness

    Time frame: baseline, 24 weeks, 26 weeks

    Maximal oxygen consumption

  5. Body Composition (%Fat)

    Time frame: baseline, 24 weeks

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Collaborators

  • National Institute on Aging (NIA)
  • National Institutes of Health (NIH)
  • University of Maryland

Registry information

Official study title

Aging, Angiogenesis and Metabolic Responses to Aerobic Exercise

Important dates

Study start
2006
Primary completion
2012
Study completion
2012
First posted
Jun 19, 2008
Registry last updated
Apr 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.