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NCT Number: NCT02433951

Exercise Tolerance in Patients With CABG and Sternotomy vs. Patients With Minimally Invasive Coronary Surgery

In this study, up to 20 healthy individuals, 20 endo-ACAB patients, and 20 CABG patients undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only). Exercise tolerance is compared between groups.

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Key information

Conditions

Coronary Artery Bypass Surgery

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jessa Hospital

Hasselt, 3500, Belgium

About this study

In this prospective observational study, up to 20 healthy individuals (no history or presence of any chronic disease, sedentary), 20 endo-ACAB patients, and 20 CABG patients (matched for age, gender and BMI) undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only).During this exercise test, following parameters are assessed at peak effort and at the second ventilatory threshold (determined by VE/VCO2 slope method): oxygen uptake (VO2), oxygen saturation (SaO2), carbon dioxide output (VCO2), resoiratory gas exchange ratio (RER), expiratory volume (VE), ventilatory equivalent for VCO2 (VE/VCO2), ventilatory equivalent for VO2 (VE/VO2), end-tidal O2 pressure (PETO2), end-tidal CO2 pressure (PETCO2), heart rate (HR), oxygen pulse (VO2/HR), cycling power output (W), tidal volume (Vt), respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), rate pressure product (RPP). Peak exercise effort is validated by RERpeak.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • undergoing this type of surgery. For healthy subjects: must be sedentary.

Exclusion criteria

  • any neurologic, nephrologic, respiratory disease. For healthy subjects: any chronic disease or condition.

Treatment and study plan

Cardiopulmonary exercise test

Other

Maximal exercise test with ergospirometry.

Primary outcomes

  1. VO2peak (peak oxygen uptake)

    Time frame: At peak exercise, single measurement which is executed between 2-4 weeks after surgery.

    Peak oxygen uptake capacity, expressed as ml/min.

Sponsors and collaborators

Lead sponsor

Hasselt University

Other

Registry information

Official study title

Exercise Tolerance in Patients With Coronary Artery Bypass Surgery (CABG) and Sternotomy vs. Patients With Minimally Invasive Coronary Surgery

Acronym: ENDO-ACAB

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
May 5, 2015
Registry last updated
Aug 19, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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