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Completed

NCT Number: NCT06702930

Exercise Timing on the Morning Blood Pressure Surge

The goal of this clinical trial was to assess the effects of morning vs. evening high-intensity interval exercise on the magnitude of the morning blood pressure surge in young healthy adults. The main questions it aimed to answer were:

* Does the timing of high-intensity interval exercise modulate the magnitude of the morning blood pressure surge? * Do sex differences exist?

Participants came in and completed a bout of high-intensity interval exercise in the morning (8-10 am) and evening (5-7 pm) as well as a no exercise control, and ambulatory blood pressure was assessed for 24 hours afterwards.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

About this study

Introductory Visit:

Participants came in for 4 visits. The first visit was an introductory visit where chronotype, eligibility for exercise, and anthropometrics were measured. This was followed by a maximal incremental exercise test to determine aerobic capacity (i.e., V̇O2peak) on a cycle ergometer, and instrumentation of an ambulatory blood pressure monitor for familiarization during daily activities and sleep.

Intervention Visits:

Three intervention visits (control, morning exercise, and evening exercise) were completed. The order was randomized using and each visit was separated by a minimum of 36 hours. Each intervention visit began by obtaining the participant's resting blood pressure and heart rate and ended with the instrumentation of the ambulatory blood pressure monitor. No exercise was performed during the control visit. The morning exercise visit included a bout of high-intensity interval exercise between 8-10 am and the evening exercise visit included a bout of high-intensity interval exercise between 5-7 pm. The high-intensity interval exercise protocol consisted of a light intensity, 3-minute warm-up at 15% peak power followed by ten 1-minute work intervals at 80% of peak power, with each interval separated by 1-minute rest intervals at 15% peak power. A 3-minute cool down was performed at 15% peak power.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion:

  • Between 18-50 years of age.
  • No history of known disease.
  • None smokers.
  • No use of chronic medications other than oral contraceptives.

Exclusion:

  • <18 years of age.
  • >50 years of age.
  • Cardiovascular disease.
  • Metabolic disease.
  • History of smoking (within the past 3 months).
  • Chronic medications (other than oral contraceptives).

Treatment and study plan

Morning high-intensity interval exercise

Other

High-intensity interval exercise was performed between 8-10 am

Evening high-intensity interval exercise

Other

High-intensity interval exercise was performed between 5-7 pm

Primary outcomes

  1. Morning blood pressure surge

    Time frame: Through study completion, an average of 4 weeks.

    The difference between morning blood pressure (the mean of the 4 blood pressure readings after awakening) and sleep-trough blood pressure (the mean of the lowest blood pressure during sleep and two adjacent blood pressure readings).

Secondary outcomes

  1. Nighttime blood pressure dip

    Time frame: Through study completion, an average of 4 weeks.

    The percent difference between daytime blood pressure (average of all blood pressure readings when participants reported being awake) and nighttime blood pressure (average of all blood pressure readings when the participant reported being asleep).

Sponsors and collaborators

Lead sponsor

University of Guelph

Other

Registry information

Official study title

The Effects of Morning vs. Evening High-intensity Interval Exercise on the Magnitude of the Morning Blood Pressure Surge

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Nov 25, 2024
Registry last updated
Nov 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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