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OpenTrials
Completed

NCT Number: NCT04336995

Exercise Pulmonary Transit Time

The study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.

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Key information

Conditions

Heart Failure, Diastolic Cardiovascular Diseases Heart Diseases Heart Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

VHVI

Nashville, Tennessee, 37232, United States

About this study

The ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. In some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. Currently, the amount of fluid is measured invasively. We have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. We now seek to find out if we can make a similar measurement after exercise. If successful, the need for catheter procedures may be reduced in certain types of heart failure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years old
  • Able to give informed consent

Exclusion criteria

  • Known allergic reaction to Definity or Optison ultrasound contrast
  • Pregnancy/Nursing - as assessed/disclosed by the participant

Treatment and study plan

contrast echocardiography

Diagnostic Test

giving echocardiographic contrast and taking echocardiographic images before and after exercise

Primary outcomes

  1. Pulmonary Transit Time

    Time frame: 3-10 seconds

    interval required for the pulmonary blood volume to traverse the pulmonary circulation

Sponsors and collaborators

Lead sponsor

Vanderbilt University Medical Center

Other

Registry information

Official study title

Echocardiographic Assessment of Pulmonary Transit Time Following Exercise

Important dates

Study start
2020
Primary completion
2021
Study completion
2024
First posted
Apr 7, 2020
Registry last updated
Apr 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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