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Completed

NCT Number: NCT07240584

Exercise Prehabilitation of Breast Cancer

This prospective prehabilitation trial evaluated the effectiveness of an individualized exercise program initiated before breast cancer surgery and maintained for 12 months. The intervention aimed to promote functional recovery and improve patient-reported outcomes.

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Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms Fatigue Hemic and Lymphatic Diseases Lymphatic Diseases Lymphedema Neoplasms Neoplasms by Site Pathological Conditions, Signs and Symptoms Postoperative Recovery Quality of Life Shoulder Dysfunction Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Balikesir Ataturk City Hospital Affiliated with University of Health Sciences

Balıkesir, Turkey (Türkiye)

About this study

Women scheduled for breast surgery due to breast cancer were enrolled in an individualized prehabilitation program that began in the preoperative period and continued for 12 months. The exercise program included range-of-motion, strengthening, and postural correction exercises delivered through supervised and home-based sessions. Outcomes were evaluated at baseline and at 1st, 3rd, 6th, and 12th months. Functional outcomes, shoulder range of motion, pain intensity, lymphedema development, and patient-reported quality of life were assessed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients diagnosed with breast cancer scheduled for surgical treatment
  • Age ≥ 18 years
  • Able to perform exercise
  • Provided informed consent

Exclusion criteria

  • Metastatic disease
  • Prior upper limb injury or neurologic impairment
  • Inability to comply with exercise program
  • Postoperative chemotherapy before the 3rd month

Treatment and study plan

Exercise-Based Prehabilitation Program

Behavioral

The exercise program was delivered to patients through both visual and written materials, accompanied by face-to-face training sessions conducted by a physiotherapist. A home-based program was designed separately for the pre-surgery phase, postoperative day 1, day 3, day 7, and the maintenance period.

The exercise template included postural correction, breathing, aerobic, stretching, and resistive strengthening exercises targeting muscles in adjacent to the shoulder joint and mobilization of scapulothoracic complex via stretching and strengthening exercises of periscapular muscles.

Primary outcomes

  1. Shoulder Range of Motion

    Time frame: baseline, 1st-3rd-6th-12th month

    Measurement of Flexion, Abduction, Internal and External Rotation of Shoulder with goniometer

  2. Pain Intensity

    Time frame: baseline, 1st-3rd-6th-12th month

    measure of pain with VAS (Visual analog scale)

  3. Functional Outcomes

    Time frame: baseline and 12th month

    measure of upper extremity functions with UEFI-15 (Upper extremity functional index) instrument

Secondary outcomes

  1. fatigue

    Time frame: baseline and 12th month

    measure of fatigue condition with FSS (Fatigue severity scale) instrument

  2. Quality of Life impairment

    Time frame: baseline and 12th month

    measure of Quality of Life with EORTC-QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire) instrument

  3. lymphedema

    Time frame: baseline and 12th month

    Limb volume difference >10% or clinical signs of edema

Sponsors and collaborators

Lead sponsor

University of Health Sciences Balikesir Hospital Eduation and Research

Other Gov

Registry information

Official study title

The Impact of Exercise Prehabilitation on Upper Extremity Range of Motions, Functionality and Quality of Life in Breast Cancer Survivors: A Prospective Clinical Trial

Acronym: Prehab of BC

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 21, 2025
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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