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Completed

NCT Number: NCT07628621

Exercise On Bone Metabolism Markers In Chronic Kidney Disease

Sixty chronic kidney disease patients, Measurement of bone turnover markers done prior to the study and at the end of the study after 6 months.

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Key information

Conditions

Chronic Kidney Diseases Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

30 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Badr university

Cairo, Egypt

About this study

Sixty chronic kidney disease patients, Measurement of bone turnover markers done prior to the study and at the end of the study after 6 months. Participants included in two groups. Group (A) received resisted exercise training on some resistance machines where; group (B) received treadmill exercise training.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Non-smokers,
  • no alcohol consumption
  • no intake of hormone replacement therapy
  • mass index ranged from 20-24 kg/m2.

Exclusion criteria

  • diabetes disorders
  • hypertension disorders
  • cardiac disorders
  • musculoskeletal disorders
  • endocrine disorders
  • intake of medications that may affect bone metabolism.

Treatment and study plan

resisted exercise training on some resistance machines

Other

resistance exercises on some resistance machines, 3 sessions of exercise training /week

treadmill exercise training

Other

treadmill aerobic exercise (intensity equal 60-80 % of each individual maximum heart rate)

Primary outcomes

  1. serum osteoprotegerin (OPG)

    Time frame: at baseline and after six month

    An overnight fasting venous blood sample was drained, centrifuged and stored at -70 °C

  2. receptor activator of nuclear factor kappa B ligand

    Time frame: at baseline and after six month

    An overnight fasting venous blood sample was drained, centrifuged and stored at -70 °C

Secondary outcomes

  1. Bone mineral density (BMD)

    Time frame: at baseline and after six month

    BMD of lumbar spine (L1-L4), proximal femur and distal radius was measured with dual-energy X-ray absorptiometry (DEXA).

Sponsors and collaborators

Lead sponsor

Badr University

Other

Registry information

Official study title

Aerobic Versus Resistance Exercise On Bone Metabolism Markers In Chronic Kidney Disease

Acronym: intervention

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 5, 2026
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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