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OpenTrials
Completed

NCT Number: NCT01879891

Exercise Intensity, Metabolic Rate and Insulin Sensitivity

The primary goal is to test the hypothesis high interval exercise increases energy expenditure and Insulin sensitivity more than 2 days of rest or moderate intensity exercise cumulatively over 23 hours during and following the exercise. Secondary goals are to evaluate exercise difficulty during moderate intensity exercise and high interval exercise as well as difficulty of activities of daily living and free living physical activity following rest, moderate intensity exercise and high interval exercise.

A secondary study is designed to evaluate potential mechanism. Hypotheses are that changes in muscle lipid metabolism, mitochondrial function, fat and cellular insulin signals will be increased following the high intensity interval exercise. In addition, these changes will be related to changes in insulin sensitivity and increases in protein metabolism and muscle damage.

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Key information

Conditions

Healthy Women Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

19 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

UAB

Birmingham, Alabama, 35294, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy premenopausal African-American or Caucasian women ages 19 - 42

Exclusion criteria

  • subjects cannot be smoking,
  • taking medications which alter energy expenditure or fuel utilization,
  • be diabetic or have a body mass index (BMI) less than 18 or more than 35.
  • Also subjects cannot be pregnant or have cardiopulmonary disease.

Treatment and study plan

AEROBIC

Other

Exercise training will consist of bicycle ergometer riding starting at 67% of heart rate max for 20 minutes. Exercise Intensity will be progressively increased every week until 80% of heart rate max for 40 minute sessions is reached.

Primary outcomes

  1. Exercise Intensity

    Time frame: 16 weeks

    To test the hypothesis that high interval exercise increases energy expenditure and Insulin sensitivity more than 2 days of rest or moderate intensity exercise cumulatively over 23 hours during and following the exercise

Secondary outcomes

  1. Exercise Difficulty

    Time frame: 16 weeks

    To evaluate exercise difficulty during moderate intensity exercise and high interval exercise as well as difficulty of activities of daily living and free living physical activity following rest, moderate intensity exercise and high interval exercise

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Important dates

Study start
1995
Primary completion
2016
First posted
Jun 18, 2013
Registry last updated
Oct 25, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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