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Completed

NCT Number: NCT02219451

Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients

The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.

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Key information

Conditions

Chronic Heart Failure

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Instituto do Coração - HC/FMUSP

São Paulo, 05403-900, Brazil

About this study

Retrospective study. Patients were recruited by database from Rehabilitation Unit of Cardiovascular Rehabilitation and Exercise Physiology of the Heart Institute (InCor). The aim of this study is to assess the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure. The investigators studied twenty-six chronic heart failure outpatients, age 30 to 70 years, functional class II to III of New York Heart Association, left ventricular ejection fraction (LVEF) ≤40% and peak oxygen uptake (VO2) ≤20. The exclusion criteria were recent myocardial infarction or unstable angina (<3 months), heart failure duration (<3 months), permanent pacemaker dependence, atrial fibrillation, skeletal muscle abnormality (e.g., arthritis) and participation in a regular exercise program. They were assigned to 2 groups: Untrained (n=13) and trained (n=13).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with chronic heart failure
  • Age 30 to 70 years
  • Functional class II to III of New York Heart Association
  • Left ventricular ejection fraction (LVEF) ≤40%
  • Peak oxygen uptake (VO2) ≤20

Exclusion criteria

  • Recent myocardial infarction or unstable angina (<3 months)
  • heart failure duration (<3 months)
  • Permanent pacemaker dependence
  • Atrial fibrillation
  • Skeletal muscle abnormality (e.g., arthritis)
  • Participation in a regular exercise program

Treatment and study plan

Exercise training

Other

exercise training

Primary outcomes

  1. Autonomic control

    Time frame: 4 months

    To asses the effects of exercise training on sympathetic modulation by analyze of autonomic control in chronic heart failure patients after 4 months protocol.Time series of muscle sympathetic nerve activity and systolic arterial pressure were analyzed by autoregressive spectral analysis

Secondary outcomes

  1. Arterial baroreflex control

    Time frame: 4 months

    To asses the effects of exercise training on arterial baroreflex by analyze of arterial baroreflex control in chronic heart failure patients after 4 months. The arterial baroreflex control was analyzed by bivariate autoregressive.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo General Hospital

Other

Collaborators

  • InCor Heart Institute

Registry information

Official study title

Exercise Training Improves Oscillatory Pattern and Arterial Baroreflex Control of Sympathetic Nerve Activity in Patients With Chronic Heart Failure

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Aug 19, 2014
Registry last updated
Aug 19, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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