Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT05980325

Exercise for Fighting Oncology Repercussions After Treatment

Cancer survival rates are currently on the verge of 70% at 5 years since diagnosis. Recent improvements in main cancer therapies including chemotherapy, radiotherapy, surgery and immunotherapy as well as developments of new biological therapies have significantly improved survival rates but unfortunately, cancer-related side effects continue to affect many patients even years after completion of main treatments. Exercise has been shown to not only ameliorate cancer-related effects before, during and after treatment but also improve disease-free and overall survival rates by decreasing risk factors associated with cancer risk and improving resilience to treatment. In this non-randomised, three-arm study, we aim to assess the effects of three forms of exercise (i.e: Nordic Walking, Aquatic Exercise and Functional Exercise) on physical performance, cancer-related fatigue, health-related quality of life and cancer-specific symptoms in a wide range of cancer survivors.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults diagnosed with cancer
  • Completion of any cancer therapy in the previous 3 months with the exception of hormonal therapy
  • Patients living within the Maresme Area
  • No contraindications for exercise (oncology clearance or Physical Activity Readiness Questionnaire negative)

Exclusion criteria

  • Patients with any neurologic, cognitive or musculoskeletal impairments that prevent them to engage in any assessment test or exercise modality.
  • Patients with unstable cardiac, respiratory or metabolic diseases
  • Unable to speak or read Catalan or Spanish

Treatment and study plan

Nordic walking

Behavioral

A 12-week Nordic Walking exercise programme supervised twice weekly

Aquatic Exercise

Behavioral

A 12-week water-based exercise training programme supervised twice weekly

functional exercise training

Behavioral

A 12-week circuit-based exercise training programme supervised twice weekly

Primary outcomes

  1. Health-Related Quality of Life

    Time frame: 12 weeks from baseline

    HRQoL measured with the EORTC Quality of Life C30 questionnaire

Secondary outcomes

  1. Cancer-related fatigue

    Time frame: 12 weeks from baseline

    Cancer-related fatigue as measure with the Brief Fatigue Inventory

  2. Cardiorespiratory fitness

    Time frame: 12 weeks from baseline

    A steady state cardiopulmonary exercise testing with breath-by-breath analysis and lactate measurement to determine submaximal cardiorespiratory fitness

  3. Estimated one-repetition maximum

    Time frame: 12 weeks from baseline

    Estimated maximal muscle strength using a linear Encoder for two main muscle groups: i) chest and ii) quads

  4. Lower limb muscle endurance

    Time frame: 12 weeks from baseline

    Lower limb muscle endurance measured as the maximum number of sit-to-stand repetitions performed in 30 seconds

  5. Functional capacity

    Time frame: 12 weeks from baseline

    Walking distance covered during a self-pace 6 minute walk test

Study contacts

Contact information is provided by the study sponsor or research team.

Esther Mur Gimeno, PhD

CONTACT

[email protected]

+34931696573

Raquel Sebio García, PhD

CONTACT

[email protected]

+34634787194

Sponsors and collaborators

Lead sponsor

Universitat Pompeu Fabra

Other

Collaborators

  • Ajuntament de Mataró
  • Col·legi de Fisioterapeutes de Catalunya

Registry information

Official study title

Exercise for Fighting Oncology Repercussions After Treatment: the EFFORT Trial

Acronym: EFFORT

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 8, 2023
Registry last updated
Dec 6, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.