Exercise CMR in (p)LF-LG AS

Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.

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Key information

Conditions

Aortic Stenosis, Severe Aortic Valve Disease Aortic Valve Stenosis Cardiovascular Diseases Heart Diseases Heart Valve Diseases Ventricular Outflow Obstruction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Goettingen

Göttingen, 37073, Germany

Location status: Recruiting

Location contact

Sören Backhaus, MD

CONTACT

[email protected]

00495513966315

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

paradoxical or conventional severe low-flow low-gradient aortic stenosis

Exclusion criteria

CMR incapable device
unable to undergo 40 min scan (can not lie flat, claustrophobia)
renal insufficiency (eGFR <30 ml/min/1.73m²)
allergy against contrast agent
unable to exercise in supine position

Treatment and study plan

Primary outcomes

Composite of events: number of participants with cardiovascular death or heart failure hospitalisation

Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of Göttingen

Other

Registry information

Official study title

Exercise CMR in (Paradoxical) Low-flow Low-gradient Aortic Stenosis

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2026
First posted: Nov 13, 2023
Registry last updated: Nov 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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