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OpenTrials
Completed

NCT Number: NCT01219647

Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis

Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Behavior Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Motor Activity Nervous System Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

UCalifornia at Los Angeles, Los Angeles, California, United States

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About this study

Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer

Exclusion criteria

  • Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of >50 on PASAT

Treatment and study plan

Exercise

Behavioral

subjects will participate in one of two forms of exercise

Stretching

Behavioral

subjects will particiopate in supervised stretching as described in arm description.

Primary outcomes

  1. Paced Auditory Serial Addition Test (PASAT)

    Time frame: 36 weeks

    test of attention and information processing

Secondary outcomes

  1. Symbol Digit Modalities Test (SDMT)

    Time frame: 36 weeks

    test of attention and information processing

  2. VO2 max

    Time frame: 36 weeks

    measure of fitness via oxygen consumption and use

  3. Long latency cognitive event related potentials ( LLCERP)

    Time frame: 36 weeks

    electrophysiologic tests of information processing

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Collaborators

  • California State University, Northridge

Registry information

Acronym: CogEx

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Oct 13, 2010
Registry last updated
Dec 9, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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