Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

This research study is a randomized controlled trial that will compare an exercise group to a control group on lower extremity function, CIPN, and inflammatory markers in ovarian or endometrial cancer patients undergoing first-line chemotherapy after surgery.

The names of the study interventions involved in this study are/is:

• Aerobic and resistance exercise; virtually supervised 16-week aerobic and resistance exercise performed at home via Zoom
• Attention control for 16 weeks, home-based stretching

The research study procedures include: screening for eligibility and study interventions including evaluations and follow up visits.

It is expected that about 30 people will take part in this research study.

Inclusion criteria

• Newly diagnosed patients with stages III-IV ovarian or endometrial cancer
• Receiving first-line carboplatin and paclitaxel chemotherapy after surgery
• ≥18 years, children under the age of 18 will be excluded due to rarity of disease
• Physician's clearance to participate in moderate-vigorous intensity exercise
• Able to read, write, and understand English
• Ability to understand and the willingness to sign an informed consent document
• Willing to undergo two venous blood draws for the study

Exclusion criteria

• Pre-existing musculoskeletal, neurological, or cardiorespiratory conditions, as determined by the treating oncologist
• Participants with uncontrolled intercurrent illness, as determined by the treating oncologist
• Participants with psychiatric illness/social situations that would limit compliance with study requirements, as determined by the treating oncologist
• Participants who have received prior chemotherapy for cancer treatment (e.g. taxanes for breast cancer)