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Completed

NCT Number: NCT01244971

Exercise and Acarbose in Type 2 Diabetes

The purpose of this study is to investigate the impact of exercise training, Acarbose, and the combination of exercise and Acarbose on glycemic control, body composition, insulin sensitivity and other cardiovascular risk markers in type 2 diabetes. Further, muscle biopsies will be obtain to study gene expression. Our hypothesis is that the combination therapy will be superior to monotherapy with exercise or Acarbose.

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Key information

Conditions

Diabetes Mellitus Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

45 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Enheten för Metabol Kontroll, Endokrinkliniken, Karolinska University Hospital

Stockholm, Stockholm County, 17176, Sweden

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Men and women, diagnosis of type 2 diabetes established since at least three months, treatment with diet or maximum one oral anti-diabetic drug, GHb < 8.5 %, age 45 - 60 years, BMI 25 - 30 kg/m2, no participation in any regular exercise program.

-

Exclusion criteria

Unable to perform exercise, significant GI-disease, severe heart-disease, renal failure

-

Treatment and study plan

Acarbose

Drug

100mg, 3 times daily

Exercise

Behavioral

Moderate combined exercise, 50 minutes 3 times per week

Exercise + Acarbose

Other

See respective monotherapy description

Primary outcomes

  1. Glycemic control

    Time frame: 12 weeks

    Glycated A1c

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Bayer
  • The Swedish Research Council

Registry information

Official study title

Effect of Exercise Training - Alone or in Combination With Acarbose - on Clinical and Metabolic Factors, and Studies of Cellular and Moleculargenetic Factors, in Type 2 Diabetes.

Important dates

Study start
2004
Primary completion
2004
First posted
Nov 22, 2010
Registry last updated
Nov 22, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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