Northeastern University
Boston, Massachusetts, 02115, United States
Location status: Recruiting
Location contact
Aaron Seitz, PhD
PRINCIPAL_INVESTIGATOR
Jinlin Liu, MA
CONTACT
Susanne Jaeggi, PhD
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07147894
The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in adolescents with and without ADHD. The main questions it aims to answer are:
* What components of executive function training contribute most to improving outcomes? * How do training components vary in their impacts on adolescents diagnosed with ADHD compared to those without a diagnosis? * What individual characteristics influence the effectiveness of executive function training?
Researchers will test six different training setups to examine which setups are the most effective for different people. They will evaluate both how well participants follow the training schedule and whether there are changes in psychological and cognitive outcomes after training.
Participants will complete:
* 40 training sessions over 4 weeks * A set of tests and surveys before and after the training * Follow-up assessments and surveys 6 months after finishing the training
Interested in participating?
Request Info12 year–17 year
All sexes
Interventional
Not applicable
Boston, Massachusetts, 02115, United States
Location status: Recruiting
Aaron Seitz, PhD
PRINCIPAL_INVESTIGATOR
Jinlin Liu, MA
CONTACT
Susanne Jaeggi, PhD
PRINCIPAL_INVESTIGATOR
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
This Single Task Training is an adaptive N-back task in which participants respond to colors and/or shapes.
Participants train on a gamified version of the N-back task, specifically, players control an astronaut that collects resources (target stimuli) needed to feed a colony and keep the technology working, while avoiding non-targets and other obstacles.
Participants train on a gamified versions of the N-back task, Complex span, Set-shifting and Inhibitory control task.
Participants in coaching conditions receive weekly, motivational coaching sessions via videoconference to (i) provide encouragement taking into account individual training performance and self-reported engagement (strength-based feedback), (ii) set realistic goals for training (time management, scheduling, and session completion plan, performance goals) while emphasizing autonomy and choice, and (iii) re-explain task and provide corrective feedback as needed.
Time frame: 40 training sessions (weeks 2-5)
An Adherence Composite will be an aggregate score between (1) Participant compliance assessed by the number of completed training sessions completed within guidelines. For each completed training session that complies with the schedule, participants will receive one point, for a total of 40 possible points; (2) Self-reported engagement: After each training session, children are asked to rate their level of engagement using a Likert scale. The dependent variable will be the average engagement rating across all completed sessions; and (3) Effort, which is assessed by fitting a curve to daily training performance with 1 point given for each session where performance is at or above 0.5 SD of the daily estimate for a total of 40 possible points. Furthermore, after each training session, children are asked to rate their level of effort put into the training using a visualized Likert scale. All adherence measures will be combined across all the measures to compute a composite score.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
A composite score across 3 working memory measures will be computed. (1) Spatial working memory span is a game-like version of the Corsi-blocks task to assess visuospatial working memory; dependent variable: maximum span length. (2) Complex working memory span is similar to Spatial working memory span but also includes a sorting task in-between encoding trials; dependent variable: maximum span length. In (3) Letter-Number Sequencing, participants are presented with a series of intermixed stimuli (e.g., letters and numbers) and recall each stimulus category separately in numerical/alphabetical order; dependent variable: maximum span length.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
A composite score across inhibitory control/set-shifting measures will be computed. (1) Continuous performance task, modeled after standard measures; dependent variable: hits minus false alarms. (2) Flanker task: classic flanker task; dependent variable: a score based upon speed and accuracy. (3) Rule Switch task a standard switching task; dependent variable: is a score based upon speed and accuracy.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
A composite across the following measures will be computed. (1) Fluid Intelligence will be measured with the UCMRT matrix reasoning task; dependent variable: number of correct responses. (2) Quantitative Skills will be assessed through a basic arithmetic task where participants quickly answer addition, subtraction multiplication, and division questions; dependent variable: number of correct responses. Finally, we test (3) Reading Speed will be assessed through a basic where short stories are read, and participants answer comprehension at the end of each passage; dependent variable: composite score of time to complete the task and number of correct responses.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
A composite score across standardized surveys to assess self-perceived stress and quality of life will be used.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
A composite across standardized surveys that capture ADHD symptoms will be used across the full sample; in addition, we will assess functional outcomes in the ADHD sample.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
We will also examine measures that we do not expect to change. Vocabulary and General Knowledge will be assessed using standardized tests that require participants to select the appropriate response among several alternatives. Dependent variable: number of correct responses.
Time frame: pre-test (week 1), post-test (week 6), and 1 follow-up session at least 6 months after post-test (week 30).
We will implement a non-trained version of the n-back task, and for those in the multi-component training group, we will also include non-trained versions of each of the trained tasks. Dependent variables: Speed and accuracy.
Contact information is provided by the study sponsor or research team.
Audrey Carrillo, MA
CONTACT
Jinlin Liu, MA
CONTACT
(774) 226-9323
Northeastern University
Other
Understanding Mediating and Moderating Factors That Determine Transfer of Working Memory Training in Adolescents
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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