Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (PET). You may know that in Alzheimer's dementia (dementia is a disease where persons become forgetful and confused), a reduction in the amount of acetylcholine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), may be responsible for some of the memory and behavioral changes. At the present time, the investigators have no clear information on the levels of acetylcholine in the brain of patients with Parkinson's disease who also have memory or behavioral changes.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Michigan Functional, Cognitive and Mobility Laboratory

Ann Arbor, Michigan, 48106, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

PDD: Patients who meet the UK Parkinson's Disease Society Brain Bank Research Center (UKPDSBRC) clinical diagnostic criteria for PD with dementia (MMSE 18-25; n=28; age 50-85 years; M/F) are eligible for the study. Hoehn and Yahr stages I-III.
PD. Patients with who meet the UKPDSBRC criteria for PD with a MMSE of >25 (n=28; age 50-85 years; M/F). Hoehn and Yahr stages I-III.
Normal control subjects (n=16) (age 50-85 years; M/F).
No current or past history of neurologic or psychiatric illness.

Exclusion criteria

Any subjects on cholinergic, anti-cholinergic drugs will be excluded from the study.
Current or past history of neurologic or psychiatric illness.

Treatment and study plan

Behavioral assessment/questionnaire

Behavioral

Complete behavioral assessment/questionnaire

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Collaborators

Michael J. Fox Foundation for Parkinson's Research

Registry information

Important dates

Study start: 2006
Primary completion: 2009
Study completion: 2009
First posted: Aug 18, 2008
Registry last updated: Jun 26, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed