Examining Endogenous Antioxidant Levels in Well Trained Cyclists

This study will investigate whether increased habitual intake of antioxidant supplements effects the concentration of endogenous antioxidants, the response of antioxidants to exercise, and differences in oxidative damage compared to a non-supplemented group.

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Key information

Conditions

Oxidative Stress

Age range

18 year–35 year

Sex eligibility

Male

Study type

Observational

Primary location

School of Sport Exercise and Rehabilitation Sciences, University of Birmingham

Birmingham, West Midlands, B15 2TT, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male,
BMI 18.8 29.9 kg/m2
cycle 3-7 times a week for durations longer than 60 minutes
cycled for a minimum of 3 years
accustomed to exhaustive cycling protocols
healthy (no known cardiovascular or metabolic disease)

Exclusion criteria

answering "NO" to any question on the general health questionnaire would result in exclusion from the study
current participation in another clinical study
current or recent smoker (last 30 days)
prescription or non-prescription of anti-inflammatory use >30 days prior to the experiment commencing or any other medications that in the opinion of the investigator may interfere with redox signalling

Treatment and study plan

Primary outcomes

Difference in Resting Levels of Endogenous Antioxidant Proteins in Skeletal Muscle - Superoxide Dismutase 2 (SOD-2)

Time frame: Protein concentrations will be measured at baseline only

To examine the effects of habitual vitamin and antioxidant supplementation on endogenous antioxidant production, participants will have a muscle biopsy taken at rest to examine any differences in endogenous antioxidant protein concentrations

Sponsors and collaborators

Lead sponsor

University of Birmingham

Other

Registry information

Official study title

The Effects of Habitual Antioxidant Supplementation on Endogenous Antioxidants and Oxidative Damage in Well Trained Cyclists

Important dates

Study start: 2013
Primary completion: 2016
Study completion: 2016
First posted: Nov 4, 2014
Registry last updated: Aug 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed