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Completed

NCT Number: NCT00244400

Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis

The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

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Key information

Conditions

Femur Head Necrosis Bone Diseases Musculoskeletal Diseases Necrosis Osteonecrosis Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

14 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Graduate School of Medicine, Osaka City University

Osaka, 545-8585, Japan

About this study

Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of avascular necrosis of the femur

Exclusion criteria

  • Old age (> 70 years)
  • Severe hepatic or renal dysfunction
  • Heart disease
  • Current use of known CYP3A-inducing or -inhibiting drugs
  • Morbid obesity

Sponsors and collaborators

Lead sponsor

Osaka City University

Other

Registry information

Important dates

Study start
2002
Study completion
2006
First posted
Oct 26, 2005
Registry last updated
Oct 17, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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