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NCT Number: NCT06919068

Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria

The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. The main question it aims to answer is:

• How prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? Participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.

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Key information

Conditions

Colorectal Cancer (CRC) Anaerobic Infection Bacteremia Bacteriaemia Bacterial Infections Bacterial Infections and Mycoses Blood Stream Infection Colonic Diseases Colorectal Cancer and Pre-cancer Polyps Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Infections Inflammation Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Rectal Diseases Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Odense University Hospital

Odense, 5000, Denmark

Location status: Recruiting

Location contact

Mark Bremholm Ellebæk, Professor

CONTACT

[email protected]

004540880511

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Older than 18 years
Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus.
Able to provide oral and written informed consent
Able to read and speak Danish

Exclusion criteria

Prior colorectal cancer diagnosis
History of stenosis of the gastrointestinal tract
Previous treatment of inflammatory bowel disease
Previous major surgery of the gastrointesinal tract (e.g. gastric bypass)
Colostomy
Pacemaker/ICD
Pregnancy or breastfeeding
Allergies to the bowel preparation regimen
Severe kidney disease
Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer)
Tumor in the colon or rectum at diagnostic imaging
Transfer to other hospital outside the region

Treatment and study plan

Colon capsule endoscopy

Diagnostic Test

PillCam Colon 2

Primary outcomes

Colorectal cancer and precancerous tumors

Time frame: 4-8 weeks after hospitalization with anaerobic gut-associated bacteria

Prevalence of colorectal cancer and precancerous tumors using colon capsule endoscopy

Study contacts

Contact information is provided by the study sponsor or research team.

Charlotte Nielsen Agergaard, MD

CONTACT

[email protected]

004565414797

Mark Bremholm Ellebæk, Professor

CONTACT

[email protected]

004540880511

Sponsors and collaborators

Lead sponsor

Odense University Hospital

Other

Registry information

Official study title

Colonic Capsule Endoscopy for Screening of Neoplasms in Patients With Anaerobic Bacteremia

Acronym: AB-care

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Apr 9, 2025
Registry last updated: Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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