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Completed

NCT Number: NCT06317844

Examination of Psychological and Physiological Pathways Linking Gratitude and Pain

The goal of this clinical trial is to compare the effects of a brief gratitude intervention on individuals' psychological and physiological responses to acute pain. Furthermore, these associations will be examined in the context of genetic variations associated with both pain and psychological processes.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Black Hills State University

Spearfish, South Dakota, 57799, United States

About this study

After being informed about the study and potential risks, all patients giving written informed consent will be randomized to a behavioral writing intervention and a cold pressor task. Participants will be randomized to a gratitude or neutral writing condition.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • must be pain-free
  • must be at least 18 years old

Exclusion criteria

  • cardiovascular disease
  • Raynaud's disease
  • epilepsy
  • being pregnant
  • having a current injury to or open cut or sore on one's non-dominant hand
  • history of fainting or seizures
  • history of frostbite in non-dominant hand
  • chronic pain conditions (e.g., fibromyalgia, neuropathy, arthritis)
  • diabetes
  • malignant tumor
  • chronic lung disease
  • liver disease
  • kidney disease
  • gastrointestinal diseases
  • currently taking opioids

Treatment and study plan

Behavioral Writing Intervention

Behavioral

This behavioral intervention will require participants to write about certain aspects of their lives.

Primary outcomes

  1. Change in Subjective Pain Ratings From Baseline to 10-minutes Post Cold Pressor Test

    Time frame: Baseline to 10 minutes post cold pressor test

    Self-reported measures of pain will be reported on a numeric scale of 0 (no pain) to 10 (strongest pain imaginable every 15 seconds throughout a cold pressor test and again 1 minute and 10 minutes post cold pressor test.

  2. Differences in Pain Tolerance to Cold Pressor Test

    Time frame: Up to 1.5 minutes of Cold Pressor Test

    Pain tolerance will be measured in terms of how many seconds individuals can keep their hand submerged in near-freezing water, for a maximum of up to 90 seconds (the task will be ended at that point).

  3. Differences in Pain Onset to Cold Pressor Test

    Time frame: Up to 1.5 minutes of Cold Pressor Test

    Pain onset will be measured in seconds between participants submerging their hands into near-freezing water and the self-reported beginning of pain.

Secondary outcomes

  1. Differences in Pain-Related Cognition

    Time frame: Immediately after the Cold Pressor Test

    The Rumination and Reappraisal subscales from the Pain-Related Cognitive Processes Questionnaire were used to assess the extent to which individuals engaged in various thought processes during the cold pressor test. Each subscale is comprised of 6-items and answered on a 0 (Not at all) to 4 (All or most of the time) scale. Scores on each item are summed to calculate an overall score which can range from 0 to 24, with higher scores indicative of greater use of each cognitive process.

  2. Differences in Autonomic Nervous System Responsivity

    Time frame: Baseline to 10 minutes post cold pressor test

    Autonomic nervous system responsivity will be assessed using levels of salivary alpha-amylase. Unstimulated whole saliva samples will be collected using the passive drool technique at the following time points: 1) immediately following completion of baseline surveys, 2) immediately following the experimental writing task, 3) 1-minute post-cold pressor test, and 4) 10-minutes post-cold pressor test.

Sponsors and collaborators

Lead sponsor

Black Hills State University

Other

Collaborators

  • National Institute of General Medical Sciences (NIGMS)

Registry information

Official study title

Examination of Psychological and Physiological Pathways Linking Gratitude and Pain and the Moderating Effects of COMT Genotype on These Associations

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 19, 2024
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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