Ex Vivo Evaluation of the Interest of the Association of Platinum With a Molecule BH3-mimetic ABT-737 in Samples of Ovarian Tumors

The aim of the study is to quantify the ex vivo induction of apoptosis by ABT-737 + association platinum in samples exposed and demonstrate the value of this combination compared to the agents used alone.

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Key information

Conditions

Ovarian Cancer Adnexal Diseases Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Ovarian Diseases Ovarian Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Centre François Baclesse

Caen, 14076, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient aged over 18 years
Ovarian cancer patients with at least five tumor samples does not affect the diagnosis, based on other tumor masses
Surgery of any initial chemotherapy naive
Patient information and signed informed consent

Exclusion criteria

A person deprived of liberty or under guardianship
Insufficient tumor samples of ovarian cancer.

Treatment and study plan

culture ex vivo with exposure to different therapeutic agents alone or in combination.

Other

When tumor resection, tumor specimens of ovarian cancer will be made towards a culture ex vivo with exposure to different therapeutic agents alone or in combination.

Primary outcomes

rate of apoptotic cells

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Centre Francois Baclesse

Other

Collaborators

GRECAN

Registry information

Acronym: ABT737 exvivo

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: Sep 26, 2011
Registry last updated: Feb 7, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed