Evaluation Report of the Urea / Urine Creatinine as a Marker of Nutritional Status Predictive of ICU Care Associated Infections

At present, many clinical studies have shown a link between malnutrition and infectious complications in intensive care particularly because of immune disorders.

Many studies testing different nutritional strategies used as the main criterion infectious complications.

So this is a robust standard, well documented in the literature as a reflection of malnutrition in intensive care, and we also want to use in our study.

In a pilot study in the surgical ICU of the Hotel-Dieu report the urea / creatinine urine as a biomarker of poor outcome of nutritional status in the ICU seems extremely discriminating in predicting the existence of nosocomial infection.

Furthermore the kinetics of the relationship between the intake and the 5th day of resuscitation, also appears to be relevant in predicting the occurrence of nosocomial infection.

Surgical ICU of the Hotel-Dieu proposes to conduct a multicenter study to confirm the relationship between the ratio of urea / creatinine urine, malnutrition marker, and nosocomial infections (NI) in intensive care.

Primary objective:

To evaluate the predictability of the ratio of urea / creatinine urinary J5 on the occurrence of nosocomial infection in intensive care.

Inclusion criteria

• 18 or more
• Admission in ICU
• Estimated length of stay superior to 5 days

Exclusion criteria

• pathologies modifying the ratio of urea / urine creatinine: end stage renal disease ( creatinine clearance less than 15 mL / min), Gastrointestinal bleeding, Right ventricular failure