Evaluation of Valvular Heart Disease Using Cardiac CT

The EVIDENTIA Registry is a multicenter study designed to evaluate valvular heart disease (VHD) using cardiac CT. It aims to assess cardiac valve anatomy, function, and myocardial characteristics through detailed CT analysis.

1. Assessing the accuracy of cardiac CT in evaluating cardiac structure, volume, function, and myocardium in VHD patients. 2. Comparing the severity, classification, and etiology (primary vs. functional) of VHD. 3. Monitoring serial changes in VHD severity via echocardiography. 4. Investigating the relationship between echocardiographic and CT-derived parameters. 5. Examining the correlation between imaging findings, VHD interventions, and patient prognosis.

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Key information

Conditions

Valvular Heart Disease Cardiovascular Diseases Heart Diseases Heart Valve Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Toho University

Ōta-ku, Tokyo, 143-8540, Japan

Location status: Recruiting

Location contact

Ethics Committee of the Toho University

CONTACT

[email protected]

81+3-5763-6534

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with at least moderate valvular heart disease who had a cardiac CT with 64 or more rows
18 years of age or older

Exclusion criteria

Less than 18 years old
Acute VHD
Infectious endocarditis
Patients with post-VHD intervention
Poor CT image quality for analyzing CT data.

Treatment and study plan

Primary outcomes

the 1-year composite endpoint of all-cause death and major cardiac adverse events (MACE) including VHD intervention.

Time frame: one year

Study contacts

Contact information is provided by the study sponsor or research team.

Hideki Koike, MD, PhD

CONTACT

[email protected]

81+3-3762-4151

Sponsors and collaborators

Lead sponsor

Toho University

Other

Registry information

Official study title

Evaluation of Valvular Heart Disease: Multicenter Registry of Noninvasive Imaging Modalities by Cardiac CT

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Apr 22, 2025
Registry last updated: May 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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