Skip to main content
OpenTrials
Completed

NCT Number: NCT07379892

Evaluatıon of TREM-1, MMP-8 and TIMP-1 Levels in Perı-Implant Crevicular Fluıd of Perı-Implanted Indıvıduals

The aim of this study was to evaluate the relationship between Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1), Matrix Metalloproteinases-8 (MMP-8) and Tissue Inhibitors of Metalloproteinases-1 (TIMP-1) levels in peri-implant crevicular fluid (PICF) in peri-implantitis patients.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Periimplantitis Mouth Diseases Peri-Implantitis Periodontal Diseases Stomatognathic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aydın Adnan Menderes University

Aydin, Turkey (Türkiye)

About this study

The aim of this study was to evaluate the relationship between TREM-1, MMP-8 and TIMP-1 levels in peri-implant crevicular fluid (PICF) in patients with peri-implantitis, and the correlation of these markers with clinical periodontal parameters.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy
  • Pregnancy or lactation

Exclusion criteria

  • osteoporosis
  • rheumatoid arthritis
  • autoimmune disease
  • diabetes

Treatment and study plan

Collection of PICF samples

Other

TREM-1, MMP-8 and TIPM-1 levels reseach in PICF samples

Primary outcomes

  1. TREM-1, MMP-8 and TIMP-1 levels in PICF samples

    Time frame: 1 month

    TREM-1, MMP-8, and TIMP-1 levels in PICF samples were measured by ELISA method

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
Feb 2, 2026
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.