Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation

The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are:

* 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients; * 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.

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Key information

Conditions

Dermatomyositis Connective Tissue Diseases Inflammation Muscular Diseases Musculoskeletal Diseases Myocardial Repolarization Myositis Nervous System Diseases Neuromuscular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Polymyositis Skin Diseases Skin and Connective Tissue Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Third People's Hospital of Hangzhou

Zhejiang, Hangzhou, 310000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form.

Clinical diagnosis of Dermatomyositis.

Exclusion criteria

Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women.

Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc.

Patients with severe lack of case data.

Treatment and study plan

disease

Other

Do you have dermatomyositis

Primary outcomes

QTc, Tp-e interval, and Tp-e/QT ratio were increased in DM patients.

Time frame: November 2011 to November 2022
the Tp-e interval and Tp-e/QT ratio were positively correlated with Inflammation.

Time frame: November 2011 to November 2022

Sponsors and collaborators

Lead sponsor

The Third People's Hospital of Hangzhou

Other

Registry information

Official study title

The Third People's Hospital of Hangzhou

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Aug 21, 2023
Registry last updated: Feb 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed