Evaluation of Toothpaste Effect in Volunteers With Dental Sensitivity

Inclusion criteria

• Healthy female and male participants (no specific gender distributions required)
• Aged 18 years or older
• Participants presenting dental hyperesthesia with at least two hypersensitive teeth with a verbal rating scale (VRS) score greater than or equal to 1 after tactile stimulation, and a Schiff Cold Air Sensitivity Scale score greater than or equal to 1 at the initial visit (T0).
• Participants certifying the truthfulness of the personal data disclosed to the investigator.
• Participants able to understand the language used at the investigation centre and comprehend the information provided by the investigator.
• Participants able to follow the instructions provided by the investigator and comply with the study requirements and restrictions.
• Pharmacological therapy (except for therapies listed under non-inclusion criteria) must have been stable for at least one month, with no changes expected or planned during the study
• Commitment by the participants not to change the daily routine or lifestyle during the study.
• Participants who have not taken part in any other similar clinical study in the previous six months.
• Commitment by the participant not to use other oral hygiene products containing fluoride or ingredients such as hydroxyapatite during the study period.

Exclusion criteria

• Participants currently participating or planning to participate in other clinical trials.
• Participants deprived of liberty by administrative or judicial decision or under guardianship.
• Participants who cannot be contacted in the event of an emergency.
• Participants admitted to a healthcare or social institution.
• Participants planning hospitalization during the study period.
• Participants who have taken part in a similar study without respecting an adequate washout period (defined as the use of desensitizing agents within the last six months).
• Participants under pharmacological treatments that modify the evaluation of dental sensitivity or are incompatible with the requirements of the study.
• Participants with a history of active caries within the past 12 months or at risk for developing caries (e.g., multiple dental restorations, crowns with compromised margins) per examiners discretion.
• Participants with known allergies or sensitivities to any components of the investigational product.
• Women who are breastfeeding, pregnant, or unwilling to take the adequate contraceptive measures to avoid pregnancy during the study (for women of childbearing potential).
• Participants with acute, chronic, or progressive pathologies (including diabetes, cardiovascular and metabolic conditions) incompatible with the study requirements.
• Any tooth surface adjacent to those surfaces under investigation that in the opinion of the investigator have any other condition that produce symptoms confounding the evaluation of cervical dentin hypersensitivity.
• Participants with a medical history or taking medication, or wearing physical items (e.g., orthodontic braces) that could interfere with the study.
• Participants with a history of illegal drug use.