Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

This is a single-centre, prospective, cross-sectional, observational study involving 40 patients with high- and low-grade parietal lobe glioma. The study investigates the prevalence of subjects who show a performance in cognitive visuo-spatial tests below the cut-off of the normative sample. It evaluates associations with patient-reported outcome measures (ADL, IADL), clinical-demographic aspects, radiological data (MRI), and histological/molecular data. Assessments occur at screening (pre-surgery), and at follow-up visits (3-4 months and 6 months post-surgery). Neuropsychological tests include Line Bisection, Bell and Letter Cancellation, Reading test, Apple Cancellation, and Fluff test.

Inclusion criteria

• Patients >18 years old
• Patients must understand the Italian Language
• Patients with suspected parietal lobe glioma

Exclusion criteria

• Tumor site other than parietal lobe.
• Patients who cannot undergo surgical resection (stereotactic/open biopsy).
• Patients who received a previous chemotherapy and/or radiotherapy treatment.
• Patients with a history of intracranial mass lesion or traumatic brain injury.
• Patients with a history of other CNS diseases (e.g., stroke, metastasis).
• Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).