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OpenTrials
Completed

NCT Number: NCT07642102

Evaluation of the Role of Early Second Look TURBT in Management of High Risk Non Muscle Invasive Bladder Cancer

The aim is to evaluate the intraoperative, postoperative and pathologic findings of early second look TURBT and the factors affecting these findings to assess the value of early second TURBT in the management of high risk NMIBC.

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Key information

Conditions

Bladder (Urothelial, Transitional Cell) Cancer Superficial (Non-Invasive) Transurethral Resection of Bladder Tumor

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain shams university

Cairo, Cairo Governorate, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients underwent initial complete resection TURBT with high risk non muscle invasive bladder cancer including: High grade T1 Any carcinoma in situ Any recurrent high grade Ta High grade Ta tumor size is more than 3 cm Any BCG failure in high grade patient Any variant histology Lymphovascular invasion High grade prostatic urethral involvement

Exclusion criteria

  • - Low risk non muscle invasive bladder cancer
  • intermediate risk non muscle invasive bladder cancer
  • muscle invasive bladder cancer
  • metastatic bladder cancer (positive lymph nodes or distant metastasis )
  • absent muscle layer in the initial TURBT biopsies
  • incomplete resection initial TURBT

Treatment and study plan

early second look transurethral resection of bladder tumor

Procedure

endoscopic early second look transurethral resection of bladder tumor after initial complete resection transurethral resection of non muscle invasive bladder tumor

Primary outcomes

  1. presence of pathologically positive tumor

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 11, 2026
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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