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Completed

NCT Number: NCT00951704

Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Tampere University Hospital, Tampere, Pirkanmaa, Finland

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • cardiac arrest
  • > 18 years of age

Exclusion criteria

  • < 18 years of age

Treatment and study plan

Primary outcomes

  1. The success rate of current guidelines (depth and frequency of chest compression, epidemiology)

    Time frame: During the resuscitation

  2. Quality of life after CA

    Time frame: 6 months

    Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt

Secondary outcomes

  1. Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2

    Time frame: During the resuscitation

  2. survival of cardiac arrest

    Time frame: hospital discharge

Other outcomes

  1. Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR

    Time frame: During resuscitation

Sponsors and collaborators

Lead sponsor

Tampere University Hospital

Other

Collaborators

  • Turku University Hospital
  • Uppsala University

Registry information

Official study title

Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.

Important dates

Study start
2008
Primary completion
2015
Study completion
2018
First posted
Aug 4, 2009
Registry last updated
Dec 13, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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