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NCT Number: NCT05412095

Evaluation of the Prognostic Value of Preoperative Quadriceps and Respiratory Muscle Thickness by Ultrasound Measurement in Cardiac and Thoracic Surgery Patients

Cardiac and thoracic surgery are major procedures. In order to estimate the operative risk, many scores have been developed, including the Euroscore 2 in cardiac surgery. However, the Euroscore has limitations since it does not assess all the parameters that may influence postoperative complications, such as the patient's general condition or the status of his or her functional reserves.

However, it has been shown that the preoperative functional reserves have a significant impact on the patient's risk of developing postoperative complications following major surgery. In addition, there is a strong association between cardiac failure and a well-described decrease in peripheral muscle lean mass (sarcopenia) in patients older than 65 years.

Usually, a nutritional assessment is performed during the pre-anesthesia consultation. This assessment is based on clinical and biological criteria that are not totally predictive of the patient's functional reserve status.

Lean body mass (muscle) is a well-validated marker for the assessment of patients' functional reserves. However, the techniques used to date are complex and require radiation.

This study aims to use ultrasound of muscle groups (respiratory muscles - Quadriceps muscle - Diaphragm) to study the relationship between preoperative muscle mass and postoperative complications in patients over 65 years of age undergoing cardiac or thoracic surgery.

This is a prospective observational study to be conducted at the Dijon University Hospital by the cardiovascular anesthesia-intensive care department. A total of 300 patients will participate in this study, and we have planned to complete the project over a 2-year period. The participating patients (if they do not present any exclusion criteria and are not opposed to inclusion) will be included and undergo a muscle ultrasound in the cardiovascular surgery department or the thoracic and pulmonary surgery department the day before their intervention.

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Key information

Conditions

Cardiac Surgery With Extracorporeal Circulation Thoracic Surgery

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Dijon Bourgogne

Dijon, 21000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient 65 years or older
  • Patients who have not objected to their inclusion in the study
  • Any patient requiring elective cardiac surgery, with extracorporeal circulation extracorporeal circulation OR
  • Any patient requiring lung surgery with resection of at least one lobe

Exclusion criteria

  • pneumectomy
  • Person who is not affiliated to national health insurance
  • Person subject to a measure of legal protection (curatorship, guardianship)
  • Pregnant, parturient or breastfeeding women
  • Major unable to express consent
  • Persons with amputations of the proximal segment of a lower limb
  • Persons suffering from a pre-existing neuromuscular pathology, tetra or paraplegia
  • Person who must undergo emergency surgery

Treatment and study plan

Ultrasound of the abdominal wall muscles

Other

the measurements will be performed during inspiration and expiration to take into account variability during the respiratory cycle. The examination is performed bilaterally and comparatively and lasts between 3 and 5 minutes.

Ultrasound quadricipital

Other

The examination is performed bilaterally and comparatively and takes between 3 and 5 minutes.

Ultrasound of the diaphragm

Other

The examination is performed bilaterally and comparatively and takes between 5 and 10 minutes.

Ultrasound of the inter-costal muscles

Other

measurements performed bilaterally on a patient in a half-sitting position at 45° and in spontaneous ventilation

Primary outcomes

  1. Onset of acute renal failure

    Time frame: Within 30 days after surgery

  2. Occurrence of a respiratory complication

    Time frame: Within 30 days after surgery

    Occurrence of acute respiratory failure in cardiac surgery and occurrence of a severe extra-respiratory complication according to the european perioperative clinical outcome definition in pulmonary surgery

  3. Occurrence of a cardiovascular complication

    Time frame: Within 30 days after surgery

  4. Occurrence of an infectious complication

    Time frame: Within 30 days after surgery

  5. Death

    Time frame: Within 30 days after surgery

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Official study title

Evaluation of the Prognostic Value of Preoperative Quadriceps and Respiratory Muscle Thickness by Ultrasound Measurement in Cardiac and Thoracic Surgery Patients: a Prospective Observational Study

Acronym: MUSCA

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 9, 2022
Registry last updated
Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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