Evaluation of the Moisturizing Effect of Study Product AV0018B and the Persistence of This Effect After Repeated Applications, Compared to an Untreated Control Area.

Inclusion criteria

• Females
• Aged 20 to 55 years, inclusive
• Phototype I to V, inclusive
• Low hairiness and absence of prominent veins on the internal and posterointernal side of the forearms.
• No shaving/hair removal of forearms
• Dehydrated forearms, with HI ≤ 35 (posterointernal side of the forearms)
• Not taking part in another clinical research study.
• Having signed the consent form.
• Having health insurance.

Exclusion criteria

Population:

• Pregnant, breastfeeding women.
• Subjects declaring to have hot flushes.
• With sunburn on forearms.
• Frequently washing their forearms for professional reasons or out of habit.
• Application of keratolytic and/or self-tanning products to the upper limbs in the 4 weeks prior to inclusion.
• Application of skin care (Hydrating, nourishing) or exfoliating products to the upper limbs in the 2 weeks prior to inclusion.
• Application of water or hygiene products to the upper limbs since the last wash on the evening before inclusion.
• Participating in another study on the forearms (not including kinetics studies) in the 2 weeks prior to inclusion.
• Participating in a kinetics study on the forearms in the 48 hours prior to inclusion.
• Subjects unable to comply with the protocol requirements.
• Subjects deprived of freedom through a legal or administrative decision, or in care or under legal guardianship.

Diseases:

• History of allergy to any of the investigational product ingredients
• Skin lesions or skin disease on the hands, arms and forearms.
• Type 1 diabetes.
• Unresolved viral hepatitis.
• Chronic cardiovascular, endocrine, rheumatological and urogenital system and non-stabilized neuropsychiatric disorders (treatment started less than 2 months ago).
• Acute pathology (infectious, inflammatory).
• Dermatological condition or skin lesion on the top of the cheekbone liable to interfere with the samplings according to the investigator's opinion.
• Any skin characteristic on the top of the cheekbone incompatible with the samplings (raised nevus, etc.) according to the investigator's opinion.

Treatments:

• Ongoing local treatment (dermocorticosteroids, retinoids, antibiotics, antifungals, etc.) or treatment applied in the 7 days prior to inclusion.
• Ongoing oral antibiotic and/or anti-inflammatory (steroid and non-steroid) or treatment taken for more than 5 consecutive days in the week before inclusion.
• Oral treatment (cardiovascular, endocrine, rheumatological, urogenital, neuropsychiatric, immunosuppressant) started in the 2 months prior to inclusion.
• Any local treatment applied to the face in the week preceding the inclusion visit
• Application of water, any rinsed or leave-on cleansing or care product on the face after the last wash performed the day before the inclusion visit