Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)

• An increase in creatinine ≥ 0.3 mg/dL (26.5 μmol/L) within 48 hours
• Or an increase in creatinine ≥ 1.5 times the baseline value
• Or a urine volume < 0.5 mL/kg/h over a 6-hour period
• Urinary Quinolinate/Tryptophan (Q/T) ratio on admission

• grad 1 : creatinine between 1.5 and 1.9 times the baseline value OR increase ≥ 0.3 mg/dL (26.5 μmol/l) and urine < 0.5 mL/kg/h over a period of 6h to 12h
• grad 2 : creatinine between 2.0 and 2.9 times the base value and urine < 0.5 mL/kg/h over a duration ≥12
• grad 3 : creatinine greater than or equal to 3.0 times the baseline value OR increase ≥ 4.0 mg/dL (353.6 μmol/L) OR use of extra-renal purification OR patients under 18 years of age with decrease in creatinine clearance < 35 mL/min per 1.73 m² and urine < 0.3 mL/kg/h over a duration of ≥24h OR anuria over a duration of ≥12h

Duration in days of ARI

• evolution of the troponin level between D1 and D7,
• Use of mechanical ventilation and duration,
• Evolution of the SOFA score between D1 and D7

Mortality within 28 days of admission to intensive care, NI-AKI

• Number of days alive outside intensive care within 28 days of admission to intensive care,
• Number of days alive not hospitalized within 28 days of admission to intensive care.