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NCT Number: NCT04211207

Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital Cardiac Arrest

It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Grenoble Alpes

Grenoble, 38043, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult >18 years
  • Admission to intensive care unit after a non-hospital cardiopulmonary arrest.
  • Resumption of spontaneous cardiac activity.
  • Non-opposition of the patient or his relatives

Exclusion criteria

  • Pregnancy
  • Prior neurological impairment
  • Persons deprived of their liberty by a judicial proceeding, or administrative decision.

Treatment and study plan

non invasive monitoring value

Other

heart's respiratory quotient as non invasive monitoring value

Primary outcomes

  1. Heart's respiratory value at H6 post intensive care unit admission to predict mortality

    Time frame: At 6 hours post intensive care unit admission

    Physiological parameter

Secondary outcomes

  1. Heart's respiratory value at intensive care unit admission to predict mortality

    Time frame: At admission of intensive care unit

    Physiological parameter

  2. Heart's respiratory value at H12 post intensive care unit admission to predict mortality

    Time frame: At 12 hours post intensive care unit admission

    Physiological parameter

  3. Heart's respiratory value at H24 post intensive care unit admission to predict mortality

    Time frame: At 24 hours post intensive care unit admission

    Physiological parameter

  4. Heart's respiratory value at intensive care unit admission to predict neurological prognosis

    Time frame: At admission of intensive care unit

    Physiological parameter

  5. Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis

    Time frame: At 6 hours post intensive care unit admission

    Physiological parameter

  6. Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis

    Time frame: At 12 hours post intensive care unit admission

    Physiological parameter

  7. Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis

    Time frame: At 24 hours post intensive care unit admission

    Physiological parameter

  8. metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission

    Time frame: At admission of intensive care unit

    Metabolic parameters

  9. metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission

    Time frame: At 6 hours post intensive care unit admission

    Metabolic parameters

  10. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission

    Time frame: At 12 hours post intensive care unit admission

    Metabolic parameters

  11. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission

    Time frame: At 24 hours post intensive care unit admission

    Metabolic parameters

  12. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission

    Time frame: At admission of intensive care unit

    Metabolic parameters

  13. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission

    Time frame: At 6 hours post intensive care unit admission

    Metabolic parameters

  14. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission

    Time frame: At 12 hours post intensive care unit admission

    Metabolic parameters

  15. Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission

    Time frame: At 24 hours post intensive care unit admission

    Metabolic parameters

  16. Cardiac arrest circumstances following Utstein-style guidelines according mortality

    Time frame: At admission of intensive care unit

    Metabolic parameters

  17. Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis

    Time frame: At admission of intensive care unit

    Cardiac arrest circumstances

  18. Vital status at day 30

    Time frame: At 30 Days post intensive car unit admission

    Alive or Dead status

  19. Cerebral performance category (CPC) score at day 90

    Time frame: At 90 Days post intensive car unit admission

    Cerebral performance category (CPC) score : CPC=1 : Conscious, alert, and oriented with normal cognitive functions, CPC=2 : Conscious and alert with moderate cerebral disability; CPC=3: Conscious with severe disability; CPC=4: Comatose or in persistent vegetative state; CPC=5 : Certified brain death or dead by traditional criteria.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital

Acronym: QUANTIC

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Dec 26, 2019
Registry last updated
Nov 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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