Evaluation of the Efficacy of a Turmeric Extract (Arantal®) in Patients With Osteoarthritis of the Knee (Gonarthrosis).

Inclusion criteria

• Patient is 40 through 80 years of age
• Subject diagnosed with femorotibial osteoarthritis of the knee (diagnosed according to the clinical and radiologic criteria of ACR),
• Patient's Assessment of Arthritis Pain measurement on the last 24 hours of at least 50 mm on VAS,
• Patient has not received any NSAIDs within 72 hours and any analgesics within 24 hours,
• Patients with chronic knee pain (i.e., knee pain at least every other day during the month preceding inclusion),
• Patients with radiologic knee osteoarthritis (Kellgren-Lawrence grade 2-4, on radiography less than 12 months old),
• Patients having signed the informed consent,
• Patients capable of comprehend the study instructions.

Exclusion criteria

• Related to the osteoarthritis pathology:

• Osteoarthritis linked to a metabolic arthropathy: chondrocalcinosis already diagnosed or defined by calcium edging on at least one femorotibial joint space, gout...,
• Predominant associated symptomatic femoropatellar osteoarthritis,
• Chondromatosis or villonodular synovitis of the knee,
• Recent trauma (< 1 month) of the knee responsible for the pain,
• Knee joint effusion justifying an evacuation through puncturing,
• Inflammatory flare (night pain, joint effusion) corresponding to a KOFUS score less than 7,
• Pathology potentially interfering with the evaluation (metabolic inflammatory arthropathy, rheumatoid arthritis, lower limb radiculalgia, arthritis...),
• Related to previous and associated treatments:

• Corticosteroids injection in the previous month, whatever the joint concerned,
• Hyaluronan injection in the evaluated knee during the previous 6 months,
• Patient who took NSAID in the 72 hours prior to inclusion or Analgesics in the 24 hours prior to inclusion,
• Slow-acting drugs for OA and/or dietary supplements taken within less than 3 months prior to the study product administration or for which the dose has been modified in the last three months (ex: chondroitin sulfate, diacerein, soy and avocado unsaponifiables, oxaceprol, granions de cuivre, glucosamine, phytotherapy for OA, homeopathy for OA...),
• Anticoagulant treatment without gastric protection,
• General corticotherapy,
• Contraindication to paracetamol.
• Related to associated pathologies:

• Patient suffering from serious associated illness (liver failure, kidney failure, non-controlled cardiovascular diseases...),
• Peptic ulcer.
• Related to patients:

• Pregnant or breastfeeding women
• Pre-menopausal women with no contraception
• Patients unable to write
• Patients enrolled in a clinical trial in the previous 3 months
• Patients under juristic protection or under guardianship.