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NCT Number: NCT06751264

Evaluation of the Efficacy and Safety of Microwave Ablation of Uterine Adenomyosis Under Improved Ultrasound Guidance

This study aims to compare the safety and efficacy of segmental power adjustment combined with uterine cavity hydro-isolation in microwave ablation of adenomyosis

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Adenomyosis of Uterus Adenomyosis Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Urogenital Diseases Uterine Diseases

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Aerospace Center Hospital

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • UFs or AM diagnosed by pathology and ultrasound；
  • Relevant symptoms such asabnormal uterine bleeding, secondary anemia, progressive dysmenorrhea and enlargement of the uterus；
  • Voluntarily undergo MWA；
  • a confirmed available safe transabdominal puncture path；

Exclusion criteria

  • Pregnancy or malignancy；
  • Severe and uncorrectable coagulation disorders；
  • Severe cardiac, liver, and renal dysfunction；
  • Anesthesia allergy.

Treatment and study plan

Peritoneal combined with intrauterine water isolation

Procedure

On the basis of the conventional peritoneal water isolation group, the improved technology group added additional intrauterine water isolation, and continued to inject ice saline to separate the endometrium on both sides.

Peritoneal water isolation

Procedure

Transabdominal injection of saline into the abdominal cavity to achieve complete separation of the uterus from the surrounding organs and structures

Primary outcomes

  1. The rates of endometrial injury

    Time frame: From enrollment to the end of treatment at 3 months

    Observe the differences in the rates of endometrial injury between two groups

Secondary outcomes

  1. The reduction rate of adenomyosis volume

    Time frame: From enrollment to the end of treatment at 1 year

    Observe the reduction rate of adenomyosis volume between two groups

  2. complication

    Time frame: From enrollment to the end of treatment at 1 year

    The complication rate between the two groups was compared

Sponsors and collaborators

Lead sponsor

Peking University Aerospace Center Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Dec 27, 2024
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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