Skip to main content
OpenTrials
Completed

NCT Number: NCT06964529

Evaluation of the Effects of I-PRF and C-PRF on Gingival Phenotype

This clinical trial aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) and concentrated platelet-rich fibrin (C-PRF) on gingival phenotype in patients undergoing mucogingival surgery with the VISTA technique. Changes in gingival thickness and width of keratinized gingiva will be assessed using both manual and digital methods.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Thin Gingival Biotype Thin Gingiva

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Inonu University Faculty of Dentistry

Malatya, Turkey (Türkiye)

About this study

The study is designed as a randomized controlled clinical trial including 30 patients, divided into two groups: I-PRF and C-PRF. All participants receive a mucogingival procedure using the VISTA technique followed by four sessions of PRF injections (one during surgery and three at 10-day intervals). The primary outcomes are changes in gingival thickness and the width of keratinized gingiva, measured manually and digitally at baseline, 1 month, 3 months and 6 months. The aim is to compare the effectiveness of I-PRF and C-PRF on soft tissue enhancement.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systemically healthy individuals (ASA I) Age between 18 and 45 years Non-smokers Gingival thickness ≤ 0.8 mm in the mandibular anterior region No restorations, missing teeth, or supernumerary teeth in the mandibular anterior region Full-mouth plaque index (PI) < 15% Full-mouth bleeding on probing (BOP) < 15%

Exclusion criteria

Presence of systemic disease or coagulation disorders Use of antibiotics or anti-inflammatory drugs within the last 3 months Smoking History of bruxism Pregnancy or lactation Ongoing orthodontic treatment Use of medications affecting gingival phenotype (e.g., calcium channel blockers, anticonvulsants) Presence of infection, lesion, or trauma at the surgical site History of periodontal surgery in the relevant area

Treatment and study plan

Concentrated PRF

Biological

Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals).

Other names: C-PRF

Injectable PRF

Biological

Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals).

Other names: I-PRF

Primary outcomes

  1. Change in gingival thickness

    Time frame: Baseline, 1 month, 3 months and 6 months.

    Gingival thickness will be measured manually (using a spreader) to assess the effect of I-PRF and C-PRF over time.

Secondary outcomes

  1. Change in width of keratinized gingiva

    Time frame: Baseline, 1 month, 3 months and 6 months

    The width of keratinized gingiva will be measured manually using a periodontal probe to evaluate the soft tissue augmentation potential of C-PRF and I-PRF.

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 9, 2025
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.