Evaluation of the Effects of Etifoxine 100 mg and Lorazepam 2 mg on Vigilance and Cognitive Functions in the Elderly

Inclusion criteria

• Man or woman aged from 65 to 75 years
• Right-handed subject (Edinburgh Handedness inventory)
• Subject having signed the consent form
• Subject having agreed to be listed on the French National Healthy Volunteers database
• Subject affiliated or beneficiary to French social insurance

Exclusion criteria

• Subject presenting a neurological or psychiatric disease notably cognitive, progressing
• Anxious subject (Hamilton score > 7 and/or Spielberger score > 51 for a man or > 61 for a woman)
• Left-handed subject (Edinburgh Handedness inventory)
• Subject presenting a not corrected visual disease or a motor function disease that could interfere with tests realization
• Smoker
• Subject taking one or more psychotropics or apparent products
• Subject having taken, during the previous month, one or more drugs that could interfere with study drugs metabolism
• Subject drinking too much coffee or tea (> 4 cups per day) or alcohol (>½ liter of wine or equivalent per day)
• Subject presenting contra-indication to one of the drugs used in the study
• Subject with past history of intolerance to drugs used in the study
• Subject not capable to use the CANTAB cognitive evaluation system
• Subject which may not be able to participate to the whole study
• Subject under tutelage or guardianship
• Subject not able to well-understand French and so to understand cognitive tests
• Subject not capable to swallow capsules
• Subject participating to another study or in exclusion period (3 months after a previous trial).