Evaluation of the Effectiveness of Ischemic Pre-conditioning on the Morbidity and Mortality of Open Surgery of Thoracoabdominal Aortic Aneurysms.

Inclusion criteria

• Patient > 18 and <85 years old
• Patient having a planned surgery for a thoracoabdominal aortic aneurysm by direct approach,
• Patient with aortic aneurysm requiring supra-visceral aortic clamping and visceral artery reconstruction,
• Aortic aneurysmal patient with or without distal femoral circulatory assistance,
• Patient with aortic aneurysm of atheromatous or dissecting etiology,
• Woman of childbearing potential with effective contraception (estrogen-progestin or intrauterine device or tubal ligation), postmenopausal woman (≥ 12 months of amenorrhea not induced by therapy)
• Patient who read and understood the newsletter and signed the consent form
• Patient affiliated with a social security scheme

Exclusion criteria

• Patient with aortic aneurysms requiring supra-visceral aortic clamping but not requiring visceral artery reconstruction (supra-visceral aortic clamping for renal aortic juxtaposition aorta),
• Patient with thoraco abdominal aortic aneurysms requiring a circulatory arrest (aortic aneurysms affecting the descending thoracic aorta or the aortic arch)
• Patient requiring emergency aortic surgery
• Patient under treatment known as interfering with PCI (Nicorandil or oral antidiabetic agents),
• Pregnant or lactating woman (negative result of baseline blood test)
• Participation in another interventional study within 28 days before randomization or during this study
• Person deprived of liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults,
• Patient under the protection of justice, patient under guardianship or curatorship.