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Completed

NCT Number: NCT07717398

Evaluation of The Effect of Injectable Platelet-rich Fibrin With Collagen Membrane in Miller Class II Gingival Recession Coverage

This study aims to evaluate the effect of injectable Platelet-Rich Fibrin (i-PRF) in combination with collagen membrane in the treatment of Miller Class II gingival recession. Gingival recession is a common periodontal condition characterized by apical displacement of the gingival margin, which may lead to aesthetic concerns, root hypersensitivity, and increased risk of root caries.

The study will include patients diagnosed with Miller Class II gingival recession. Participants will be treated using a regenerative periodontal surgical approach involving coronally advanced flap combined with injectable platelet-rich fibrin and collagen membrane. Clinical parameters such as recession depth, clinical attachment level, and keratinized tissue width will be evaluated before and after treatment at specific follow-up intervals.

The objective is to compare the effectiveness of this combined regenerative approach in improving root coverage and soft tissue healing, and to assess its potential benefits in periodontal regeneration and esthetic outcomes.

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Key information

Conditions

Gingival Recession (Miller II) Gingival Diseases Gingival Recession Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dentistry ,Tanta university

Tanta, Gharbia Governorate, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Both males and females of age ≥ 18

Exclusion criteria

History of systemic diseases (i.e. diabetes, autoimmune dysfunction, prolonged cortisone therapy, or chemotherapy) that contraindicated periodontal surgical treatment.

Treatment and study plan

Group (1)

Procedure

Application of injectable platelet -rich fibrin (I-PRF) in combination with a collagen membrane during the surgical procedure to enhance soft and hard tissue healing

Other names: I-PRF+collagen membrane

Group 2

Procedure

coronally advanced flap surgery combined with a subepithelial connective tissue graft for the treatment of gingival recession defects

Other names: CAF+ SCTG

Primary outcomes

  1. Keratinized Tissue Thickness

    Time frame: Baseline, 1 month ,3 months and 6 months after surgery

    measured in millimeters (mm) using a endodontic file

Secondary outcomes

  1. Recession Depth (RD)

    Time frame: baseline,1 month,3 months,6 months after surgery

  2. Recession Width (RW)

    Time frame: Baseline,1 month,3 months ,and 6 months after surgery

  3. keratinized Tissue Height (KTH)

    Time frame: Baseline, 1 month, 3 months, 6 months after surgery

  4. Probing Pocket Depth (PPD)

    Time frame: Baseline and 6 months after surgery

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 21, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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