Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery

The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery.

The aim of this study is to evaluate whether there is a difference in preoperative and postoperative pain and functional status between patients with and without central sensitization with knee osteoarthritis.

When the literature was reviewed, it was seen that central sensitization was one of the important mechanisms that caused pain in knee osteoarthritis, and it was determined that this had negative consequences in terms of postoperative pain and improvement in functional status. In this study, the effect of central sensitization on the results will be investigated by evaluating pain and functional status before and after knee total joint prosthesis in two groups of knee osteoarthritis patients, with and without central sensitization, and by comparing the groups.

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Key information

Conditions

Central Sensitisation Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Signs and Symptoms

Age range

60 year–75 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of primary knee osteoarthritis
Planning for total joint replacement surgery for the knee
Being between the ages of 60-75

Exclusion criteria

Having secondary knee osteoarthritis
Planning for knee total joint prosthesis revision
Having uncontrolled systemic disease (such as diabetes mellitus, hypertension, thyroid disease)
Having neuromuscular disease
Having a body mass index over 40

Treatment and study plan

Total knee arthroplasty

Procedure

Patients already admitted for total knee arthroplasty for knee osteoarthritis will have the procedure as planned

Primary outcomes

Knee pain

Time frame: Preoperative, 1 month postoperative and 3 months postoperative

Knee pain will be assessed with numerical rating scale, where the patients rate their pain on a scale from 0 to 10 where 0 means no pain and 10 means the most severe pain they can imagine.

Secondary outcomes

Functional Status

Time frame: Preoperative, 1 month postoperative and 3 months postoperative

Functionality of the patients will be assessed with WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index). Responses are typically rated on a scale from 0 (none) to 4 (extreme). Higher scores indicate greater impairment.

Study contacts

Contact information is provided by the study sponsor or research team.

Berk Korkut

CONTACT

[email protected]

+905305202866

Fatma Merih Akpınar

CONTACT

[email protected]

+905333558843

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2026
First posted: Aug 14, 2024
Registry last updated: Aug 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed