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NCT Number: NCT04461002

Evaluation of the Correlation Between Molecular Phenotype and Radiological Signature (by PET-scanner and MRI) of Incident WHO II and III Grade Gliomas.

From the medical records of a series of patients operated on for incident grade II and III glioma, the primary objective is to evaluate the correlation between the molecular profile of tumours and preoperative imaging data (by FDG and FDOPA PET-scan and multimodal MRI).

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Key information

Conditions

Glioma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Privé Clairval

Marseille, 13009, France

About this study

A retrospective monocentre study of medical data (clinical, histological, molecular and imaging) contained in the medical records of patients operated on for Grade II or III incident glioma.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject 18 years of age or older, having been informed of the research
  • Subject operated on with an incident glioma of grade II or III, histologically confirmed (WHO 2016 classification)
  • Subject for which all preoperative imaging data is available (MRI, FDG and FDOPA PET-scan)
  • Subject for which molecular data of the lesion are available

Exclusion criteria

  • Subject having signified his opposition to the use of his medical data
  • Subject under safeguard of justice, guardianship or trusteeship
  • Subject with incomplete or missing part of the molecular and/or imaging data

Treatment and study plan

retrospective analysis

Other

Evaluate the correlation between tumour molecular profile and preoperative imaging data (FDG and FDOPA PET-scan and multimodal MRI).

Primary outcomes

  1. Primary outcome

    Time frame: 4 years

    Evaluate the correlation between tumour molecular profile and preoperative imaging data (FDG and FDOPA PET-scan and multimodal MRI).

Secondary outcomes

  1. Molecular profile

    Time frame: 4years

    Evaluate the overall survival and progression-free survival of patients based on the molecular profile of gliomas.

  2. Imaging data

    Time frame: 4 years

    To evaluate the overall survival and progression-free survival of patients based on imaging data (PET-scan and MRI) of gliomas.

Sponsors and collaborators

Lead sponsor

GCS Ramsay Santé pour l'Enseignement et la Recherche

Other

Registry information

Official study title

Evaluation of the Correlation Between Molecular Phenotype and Radiological Signature (by PET-scanner and MRI) of WHO II and III Grade Incident Gliomas.

Important dates

Study start
2019
Primary completion
2024
Study completion
2024
First posted
Jul 8, 2020
Registry last updated
Jul 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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