Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy

Patients who have doubt for ectopic pregnancy will be enrolled for our study. These patients will be determined with using irregular increased human chorionic gonadotropin (beta-HCG) results and no embryo reported ultrasonography results. Plasma and cervical fluid samples will be taken from these patients and axonemal dynein heavy chain 5 and creatine kinase levels of samples will be compared between patients who have doubt for ectopic pregnancy and patients who have intrauterine pregnancy. Concentration of these proteins in samples will be evaluated. If any difference will be found between groups in favour of ectopic pregnancy, these results might be interpreted as these proteins useful for early detecting of the ectopic pregnancy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ectopic Pregnancy Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Pregnancy, Ectopic Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Ege University, Medicine Faculty, Department of Obstetrics and Gynecology

Izmir, 35100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Doubted ectopic pregnancy
Without any finding about intrauterine pregnancy in ultrasonography results
Without any vaginal bleeding
Having irregular pregnancy test results
Beta-HCG results should be at least upper than 100 milli-International unit (mIU/ml)
Having fist trimester pregnancy for intrauterine pregnancy group
Without any emergency findings

Exclusion criteria

Doubted incomplete abortion
Having vaginal bleeding
Having ultrasound results which include intrauterine embryo report
Having lower than 100 mIU/ml beta-HCG results
Without fetal heart rate in intrauterine pregnancy group
Having older than fist trimester pregnancy for intrauterine pregnancy group
Having emergency findings

Treatment and study plan

Collecting cervical liquid and sera samples

Other

Primary outcomes

Concentration of Axonemal Dynein Heavy Chain 5

Time frame: 1 year
Concentration of creatine kinase

Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Ege University

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Dec 16, 2016
Registry last updated: Mar 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed