Evaluation of the Anti-VZV Vaccine Response of Patients With Immune-mediated Systemic Inflammatory Diseases Vaccinated in the Care Setting

Vaccination with the recombinant anti-VZV vaccine (Shingrix) is carried out as part of treatment in all immunocompromised patients over 18 years of age, in accordance with HAS recommendations (the vaccination schedule requires 2 doses 2 months apart).

The vaccine response will be measured during hospitalisation and/or follow-up consultations, using the same sample as that used to monitor MIMI in the same laboratory (Immunology Laboratory, CHU Bichat).

Clinical and biological data will be collected to study factors associated with vaccine response, vaccine tolerance and MIMI activity.

Information relating to diagnosis, examinations and follow-up will be collated in the patient's medical file.

Patients are systematically seen every 6 months for follow-up consultations as part of their MIMI.

No additional visits are planned for research purposes.

Inclusion criteria

• Patient over 18 years of age being managed for MIMI, including
• Systemic lupus
• Gougerot-Sjögren's syndrome
• Systemic scleroderma
• Mixed connectivitis
• Inflammatory myositis
• Systemic sarcoidosis
• Systemic vasculitis (necrotizing vasculitis and giant cell arteritis)
• Behçet's disease
• Adult Still's disease
• IgG4-associated disease
• Autoimmune cytopenias (autoimmune hemolytic anemia, immunological thrombocytopenic purpura, Evans syndrome)
• Susac syndrome
• Followed in the internal medicine department of Hôpital Bichat, Paris
• Justifying VZV vaccination due to immunosuppression or age over 65.
• Vaccinated as part of care between June 2025 and June 2026
• Regardless of history of shingles
• With a serum sample available for analysis
• Having received at least the first dose of the vaccine regimen (in hospital or in the community)

Exclusion criteria

• Evolving cancer, with or without treatment (chemotherapy, immunotherapy, etc.)
• History of VZV vaccination (live or recombinant)
• Patient who has had an allergic reaction to a vaccine
• Pregnancy
• Patient under legal protection, guardianship or trusteeship
• Not affiliated to a social security scheme (general or CMU)
• Patient unable to understand research information
• Absence of non-opposition