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NCT Number: NCT04953507

Evaluation of T2, T3 Sympathectomy for Postmastectomy Pain Syndrome by Pulse Oximeter

The aim of the study is to compare the efficacy of T2, T3 sympathetic block using thermal radiofrequency versus chemical neurolysis in postmastectomy pain syndrome using perfusion index derived from pulse oximetry.

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Key information

Conditions

Analgesia Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Walaa Y Elsabeeny

Cairo, 11796, Egypt

About this study

Postmastectomy pain is a chronic pain condition with neuropathic nature. Several drugs and methods are used for its management. This study was designed to compare the efficacy of both thermal radiofrequency and chemical neurolysis in management of postmastectomy pain through using perfusion index derived from pulse oximetry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients with postmastectomy pain syndrome
  • ≥ Age 18 years
  • ASA II-III

Exclusion criteria

  • patient refusal
  • coagulation defects
  • abnormal kidney or liver functions
  • local infection at site of injection
  • bone metastases
  • severe cardiorespiratory disease

Treatment and study plan

Thermal Radiofrequency

Procedure

Radiofrequency lesioning at level of T2 and T3 using 80°c for 120 seconds

Chemical Neurolysis

Procedure

injection of 1.5 ml of the chemical neurolytic agent (phenol in saline 8%) at each level

Primary outcomes

  1. Visual analogue score

    Time frame: up to 24 weeks

    minimum score 0 and maximum score 10

Secondary outcomes

  1. Perfusion index trend

    Time frame: procedure time

    measuring the change in perfusion index in the ipsilateral limb after the procedure compared to pre-procedural

  2. Opioid consumption

    Time frame: up to 24 weeks

    average opioid consumption

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Evaluation of T2, T3 Sympathectomy for Postmastectomy Pain Syndrome by Thermal Radiofrequency Versus Chemical Neurolysis Using Perfusion Index Derived Pulse Oximeter

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Jul 8, 2021
Registry last updated
Jul 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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