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NCT Number: NCT05996497

Evaluation of Speech Rhythm Training in Dyslexic Readers Aged 7 to 9 Years

Studies of dyslexia have shown altered oscillatory activity in the low gamma band (~25-35 Hz) in the left auditory cortex. Neural oscillations around 30 Hz constitute the basic sampling rate of speech, from which the ability to form specific phonemic categories on which reading learning is based is derived. An alteration of the oscillatory activity at 30 Hz could therefore influence the ability of children to learn to read, and explain the reading deficit observed in children with a specific written language disorder. The objective of our study is to determine whether intensive rhythmic auditory stimulation applied during 30 sessions of 15 minutes spread over 6 weeks (5 sessions per week) can correct neural oscillations in the gamma-low band, allowing an improvement of phonemic categorization abilities, and thus the reading abilities of dyslexic readers aged 7 to 9 years. The long-term objective of this study is to test the therapeutic potential of auditory stimulation with speech rhythms for the treatment of reading disorders.

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Key information

Age range

7 year–9 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institut de l'Audition

Paris, France

Location status: Recruiting

Location contact

Diane Lazard, MD

CONTACT

About this study

Longitudinal cross-over study carried out on 4 experimental groups to compare the effect of two rhythmic auditory trainings (30 Hz and low frequencies) compared to the effect of a grapho-phonological correspondence training (GraphoGame).

The study begins with a recruitment and inclusion period after diagnosis of dyslexia. During this study, 4 assessments are performed and include behavioral measures in the care setting and electrophysiological measures in the research setting:

  • at time T1 before any remediation,
  • at T2 after the first training,
  • at T3 at most 7 days after the 2nd training session,
  • at T4 seven weeks after T3.

After the T1 assessment, participants were randomized into 4 different groups (training 1 then training 2):

Group 1 : Auditory Rhythmic at 30 Hz then GraphoGame Group 2 : GraphoGame then Rhythmic Auditory at 30 Hz Group 3 : Auditory Rhythmic at low frequencies then GraphoGame Group 4 : GraphoGame then Auditory Low Frequency Rhythmic The first training period (total duration 6 weeks) according to the assigned group begins and takes place at the speech therapist's office and at home.

After the T2 evaluation, the 2nd training period (total duration 6 weeks) according to the assigned group begins and takes place at the SLP's office as well as at home.

The post-training evaluations T3 and T4 take place, respectively, 1 week and 7 weeks after the last training.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • between 7 and 9 years old
  • in regular schooling
  • have a diagnosis of dyslexia
  • have a non-verbal intelligence assessment within the norm. Inclusion assessments must show a major reading disability without associated cognitive deficits.
  • be equipped with a PC at home
  • have given their assent and whose parents/legal guardians have given their oral consent

Exclusion criteria

  • have any other diagnosis of language impairment
  • have a neurological disorder (visual, auditory, executive)
  • have an associated psychiatric disorder
  • have a developmental delay.

Treatment and study plan

Behavioral measures

Behavioral

behavioral measures

Electrophysiological measures

Other

Electrophysiological measures

Training 1

Other

Training 1

Training 2

Other

Training 2

Primary outcomes

  1. Comparison of reading accuracy by measuring the percentage of correct responses in the isolated pseudoword reading task between rythmic auditory training condition vs. grapho-phonological mapping training (GraphoGame).

    Time frame: 2 years

    Comparison of reading performance is assessed in terms of both accuracy and speed. High percentage of correct responses means that children improve their reading accuracy.

  2. Comparison of reading speed by measuring reading time in the isolated pseudoword reading task between rythmic auditory training condition vs. grapho-phonological mapping training (GraphoGame).

    Time frame: 2 years

    Comparison of reading performance is assessed in terms of both accuracy and speed. A short time means that children improve their reading speed.

Secondary outcomes

  1. Measurement of reading accuracy (percentage of correct responses in the isolated pseudoword reading task) between multiple conditions.

    Time frame: 2 years

    Reading accuracy compared between rhythmic auditory training then grapho-phonological mapping training vs. grapho-phonological mapping training then rhythmic auditory training and rhythmic auditory training at 30 Hz vs. rhythmic auditory training at 3.5 Hz

  2. Measurement of reading speed (reading time in the isolated pseudoword reading task) between multiple conditions.

    Time frame: 2 years

    Reading speed compared between rhythmic auditory training then grapho-phonological mapping training vs. grapho-phonological mapping training then rhythmic auditory training and rhythmic auditory training at 30 Hz vs. rhythmic auditory training at 3.5 Hz

Study contacts

Contact information is provided by the study sponsor or research team.

Anne-Lise Giraud, PhD

CONTACT

[email protected]

+33176535054

Sophie Bouton, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Institut Pasteur

Industry

Collaborators

  • Institut de l'Audition

Registry information

Acronym: RnDys

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Aug 18, 2023
Registry last updated
Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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