Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes

Each group of patients will receive specific interventions, as follows: 0.075% Cetylpyridinium Chloride mouthwash (Group 1); 0.075% Cetylpyridinium Chloride associated with 0.28% zinc lactate mouthwash (Group 2), negative control, distilled water (Group 3). To monitor the viral load, the following procedures will be performed: saliva collection, in time intervals before mouth rinsing with the solutions at baseline (T0), immediately after (T1), 30 min (T2), and 1 hour after mouth rinses (T3). SARS-CoV-2 will be quantified by Real Time quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays.

Inclusion criteria

• positive for SARS-CoV-2 by the RT-PCR method,
• in common bed for minimum of 1 day and maximum of 5 days,
• ensuring that patients are no more than 10 days since showing the first symptoms,
• who are positive for SARS-CoV-2 in the first collection of oral fluid and saliva, and
• who demands oral hygiene care and other preventive and therapeutic dental procedures.

Exclusion criteria

• pediatric patients, t
• hose who tested negative for SARS-CoV-2 by the RT-PCR method at the time of recruitment or at the time of first oral fluid and saliva collection;
• those who exhibit oral ulcerations and other erosive lesions in the oral mucosa, which contraindicate the use of cetylpyridinium;
• patients who have bleeding in the oral cavity which prevents sample collections; patients who report history of allergy, irritations or other side effects derived from the use of these substances;
• patients who do not adhere to oral care protocols or those in whom it was not possible to perform these procedures.