Skip to main content
OpenTrials
Completed

NCT Number: NCT03871114

Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Oral Lichen Planus Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Dentistry

Cairo, 11431, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP.
  • Patients free from any other oral lesions
  • cooperative patients who agrees to take the supplied medications.
  • Patients who are systemically healthy

Exclusion criteria

  • Patients suffering from any systemic disease.
  • Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
  • Treatment with any oral topical medications for at least four weeks prior to the study.
  • Pregnant and lactating women.

Treatment and study plan

Triamcinolone Acetonide in orabase

Drug

treatment of OLP with topical steroid

Other names: topical corticosteroid

Primary outcomes

  1. Measurement of salivary levels of miR-155 in OLP before treatment

    Time frame: baseline

    assessment of miR-155 in saliva of patients with OLP before treatment

  2. Measurement of salivary levels of IL-10 in OLP before treatment

    Time frame: baseline

    assessment of IL-10 in saliva of patients with OLP before treatment

Secondary outcomes

  1. Measurement of salivary levels of miR-155 in OLP after treatment

    Time frame: 4 weeks

    assessment of miR-155 in saliva of patients with OLP after treatment

  2. Measurement of salivary levels of IL-10 in OLP after treatment

    Time frame: 4 weeks

    assessment of IL-10 in saliva of patients with OLP after treatment

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Evaluation of Salivary Levels of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Mar 12, 2019
Registry last updated
Jul 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.